Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
EUR
Contact rapide
Veuillez m'envoyer plus d'informations sur
Halo-PEG(2)-Azide
Nom chimique: 1-Azido-12-chloro-3,6-dioxadodecane // Synonymes: 1-(2-(2-Azidoethoxy)ethoxy)-6-chlorohexane
- n° Art.:RL-3700
- n° CAS:2568146-55-2
- Formule:C10H20ClN3O2
- Storage temperature:-20°C
- Masse moléculaire:249,74 g/mol
from 300,00 €
description
This chloroalkane linker serves as ligand for a specific modified bacterial haloalkane dehalogenase. This is a reporter protein whose sequence can easily be fused to a gene of interest. The reaction between the chloroalkane linker and the enzyme is fast and irreversible under physiological conditions and the system has been used extensively to measure protein-protein interactions in cells.
Furthermore, the additional azide moiety serves clickable moiety.
references
HaloTag technology: a versatile platform for biomedical applications; C. G. England, H. Luo and W. Cai; Bioconjug Chem 2015; 26: 975-86. https://doi.org/10.1021/acs.bioconjchem.5b00191.
HaloTag: a novel protein labeling technology for cell imaging and protein analysis; G. V. Los, L. P. Encell, M. G. McDougall, D. D. Hartzell, N. Karassina, C. Zimprich, M. G. Wood, R. Learish, R. F. Ohana, M. Urh, D. Simpson, J. Mendez, K. Zimmerman, P. Otto, G. Vidugiris, J. Zhu, A. Darzins, D. H. Klaubert, R. F. Bulleit and K. V. Wood; ACS Chem Biol 2008; 3: 373-382. https://doi.org/10.1021/cb800025k.
HaloTag-Targeted Sirtuin-Rearranging Ligand (SirReal) for the Development of Proteolysis-Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 (Sirt2); M. Schiedel, A. Lehotzky, S. Szunyogh, J. Oláh, S. Hammelmann, N. Wössner, D. Robaa, O. Einsle, W. Sippl, J. Ovádi, M. Jung; ChemBioChem 2020; 21(23): 3371-3376. https://doi.org/10.1002/cbic.202000351.
Selection of DNA-Encoded Libraries to Protein Targets within and on Living Cells; B. Cai, D. Kim, S. Akhand, Y. Sun, R. J. Cassell, A. Alpsoy, E. C. Dykhuizen, R. M. Van Rijn, M. K. Wendt, C. J. Krusemark; J. Am. Chem. Soc. 2019; 141(43): 17057-17061. https://doi.org/10.1021/jacs.9b08085.
* Disclaimer
We refer to our general terms and conditions.
All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
Besoin d'informations supplémentaires sur ce produit?
entrer en contact
Brochures et dépliants
Des produits qui pourraient également vous intéresser!
