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SNAP-acid
Nom chimique: 5-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)amino)-5-oxopentanoic acid // Synonymes: SNAP-COOH, Carboxy-SNAP, BG-acid, BG-COOH
- n° Art.:RL-3835
- n° CAS:881663-34-9
- Formule:C18H20N6O4
- Storage temperature:2-8°C
- Masse moléculaire:384,40 g/mol
from 600,00 €
description
RL-3835 is carboxy-functionalized benzylguanine (BG), allowing for further drivatization with amino or hydroxy-functionalized labels or linkers. The BG moiety reacts specifically and rapidly with the so-called SNAP-tag, a polypeptide protein tag, allowing irreversible and covalent labeling of SNAP fusion proteins.
references
Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology; T. Podewin, J. Ast, J. Broichhagen, N. H. F. Fine, D. Nasteska, P. Leippe, M. Gailer, T. Buenaventura, N. Kanda, B. J. Jones, C. M’Kadmi, J.-L. Baneres, J. Marie, A. Tomas, D. Trauner, A. Hoffmann-Röder, D. J. Hodson; ACS Cent. Sci. 2018; 4(2): 166-179. https://doi.org/10.1021/acscentsci.7b00237
SNAP-Tag Technology: A Useful Tool to Determine Affinity Constants and Other Functional Parameters of Novel Antibody Fragments; J. Niesen, M. Sack, M. Seidel, R. Fendel, S. Barth, R. Fischer, C. Stein; Bioconjugate Chem. 2016; 27(8): 1931-1941. https://doi.org/10.1021/acs.bioconjchem.6b00315.
A general method for the covalent labeling of fusion proteins with small molecules in vivo; A. Keppler, S. Gendrezig, T. Gronemeyer, H. Pick, H. Vogel, K. Johnsson; Nat. Biotechnol. 2003; 21: 86-89. https://doi.org/10.1038/nbt765.
Directed evolution of O6-alkylguanine-DNA alkyltransferase for efficient labeling of fusion proteins with small molecules in vivo; A. Juillerat, T. Gronemeyer, A. Keppler, S. Gendreizig, H. Pick, H. Vogel, K. Johnsson; Chem. Biol. 2003; 10(4): 313-317. https://doi.org/10.1016/s1074-5521(03)00068-1.
Site-specific, Covalent Labeling of Recombinant Antibody Fragments via Fusion to an Engineered Version of 6-O-Alkylguanine DNA Alkyltransferase; F. Kampmeier, M. Ribbert, T. Nachreiner, S. Dembski, F. Beaufils, A. Brecht, S. Barth; Bioconjugate Chem. 2009; 20(5): 1010-1015. https://doi.org/10.1021/bc9000257.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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