Workshop Prevention of Aspartimide Formation

Workshop Prevention of Aspartimide Formation

Published on 23.09.2021

You missed our workshop featuring Prof. Dr. Jeffrey W. Bode (ETH Zurich)? Any further questions? Please get in contact via info@iris-biotech.de
Workshop Prevention of Aspartimide Formation

Highlights


  • General Introduction (Dr. Markus Weishaupt; Project Manager; Iris Biotech)
  • Expert Talk: "Research Insights“ (Prof. Dr. Jeffrey W. Bode; Principal Investigator; ETH Zurich)
  • Q&A

Speakers

Jeffrey Bode Prof. Dr. Jeffrey W. Bode Special Guest
Principal Investigator at ETH Zurich
Markus Weishaupt Dr. Markus Weishaupt Project Manager
Iris Biotech
Raimund MaierDr. Raimund Maier Chair
Project Manager at Iris Biotech

Recording

Related publication

Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups; Neumann, K.; Farnung, J.; Baldauf, S.; Bode, J. W.; Nat. Commun. 2020, 11, 982.
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Related posts

 

Measures to Prevent Aspartimide Formation
Aspartimide formation remains one major hurdle during peptide synthesis. Read on to find out more about different strategies and available products at Iris Biotech in order to avoid this side product.
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Bulky Aspartate Protecting Groups to Avoid Aspartimide Formation
Frustrated by aspartimide formation during peptide synthesis? Iris Biotech presents aspartate derivatives with bulky side chain protecting groups that minimize the formation of aspartimide-related side-products.
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PotM: Asp(CSY) – Tackling Aspartimide Formation
Fmoc-Asp(CSY)-OH – an innovative building block to suppress aspartimide formation during peptide synthesis by utilizing cyanosulfurylide as carboxylic acid protecting group.
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Improved Synthesis with Dmb-Glycine Dipeptide Building Blocks
Positions next to Glycine are often reasons for side reactions, as aspartamide or diketopiperazine formation can occur. Dmb and Tmb can be used for temporary protection of the amide nitrogen of a peptide bond, in order to solubilize the peptide and increase yield and purity.
Read more

Related products

 

Fmoc-L-Asp(OMpe)-OH

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-aspartic acid beta-3-methylpentyl ester
Product code: FAA8120
Formula: C25H29NO6
MW: 439,51 g/mol

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Fmoc-L-Asp-OMpe

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-aspartic acid alpha-3-methylpentyl ester
Product code: FAA8090
Formula: C25H29NO6
MW: 439,51 g/mol

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Fmoc-L-Asp(OBno)-OH

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-aspartic acid beta-(5-butylnon-5-yl) ester
Product code: FAA8125
Formula: C32H43NO6
MW: 537,70 g/mol

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Fmoc-L-Asp(CSY)-OH

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-aspartic acid cyanosulfurylide
Product code: FAA8480
Formula: C23H22N2O5S
MW: 438,50 g/mol

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Fmoc-D-Asp(CSY)-OH

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-D-aspartic acid cyanosulfurylide
Product code: FAA8483
Formula: C23H22N2O5S
MW: 438,50 g/mol

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Fmoc-L-Asp(OEpe)-OH

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-aspartic acid beta-3-ethylpentyl ester
Product code: FAA8235
Formula: C26H31NO6
MW: 453,54 g/mol

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Fmoc-DmbGly-OH

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-alpha-(2,4-dimethoxybenzyl)-glycine
Product code: FAA3390
Formula: C26H25NO6
MW: 447,48 g/mol

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Fmoc-TmbGly-OH

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-alpha-(2,4,6-trimethoxybenzyl)-glycine
Product code: FAA3400
Formula: C27H27NO7
MW: 477,51 g/mol

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