Blog | Page 47

Fast and Easy Protease Kinetics with Asymmetric Rhodamine 110 Substrates

Asymmetric Rhodamine 110 protease substrates are used for the determination of protease kinetics. The asymmetric structure of these dyes greatly simplifies the determination of enzyme kinetics, while the properties of Rhodamine 110 facilitate an uncomplicated readout.

THPTA: Ligand-accelerated Click Chemistry in Aqueous Solution

Polytriazole ligands such as THPTA accelerate the copper-catalyzed azide-alkyne cycloaddition (CuAAC), or “Click”, reaction. Moreover, with the use of further additives, polytriazoles facilitate CuAAC even in live cells by significantly lowering the bioavailability of the copper catalyst.

Markers for the Quality of Food

Maillard Reaction Products (MRPs) result from the reaction of Arg and Lys side chains with reducing carbohydrates. MRPs are valuable markers for food quality and are used in many different branches of industry such as food, pharma, cosmetics and biochemistry.

3rd Annual Peptides Congress, London

April 18th-19th, 2016
London, UK

Scientific discussions about the current results and future challenges of peptides research and therapeutics will be the main topic of this meeting.

Furyl-Alanine: A Novel Photo-Click Amino Acid

2-Furyl-alanine can be incorporated into peptides via SPPS or by using enzymatic approaches. UV-irradiation in the presence of oxygen and a photosensitizer converts furyl-alanine to an intermediate that selectively reacts with certain nucleophiles. This property can be employed for site-specific labeling of peptides and proteins.

Targeted and Reversible Biotinylation with Biotin-SS-Tyramide

Our new Biotin-SS-Tyramide linker is a valuable tool for peroxidase-promoted targeted protein biotinylation. By using peroxidase-tagged antibodies, proteins and protein clusters can be selectively biotinylated, and then isolated using streptavidin. The biotin tag can be subsequently removed using reducing agents (e.g. glutathione).

Fmoc-Phe-Aca: Fluorescent Internalization Reporter for Cell Penetrating Peptides (CPPs)

The Fmoc-L-Phe-Aca pseudo-dipeptide is a useful reporter group for the successful internalization of CPPs. Phe quenches the fluorescence of Aca. Internalization of the peptide containing Phe-Aca leads to proteolytic cleavage of the Phe-Aca bond and thus to fluorescence.

3rd Belgian Peptide Group Meeting

February 17th-18th, 2016
Brussels, Belgium

This meeting intends to cover various aspects in peptide world: drug discovery and development, pharmacology, structure-activity relationship, drug delivery, synthesis, identification and characterization.

23èmes Journées Jeunes Chercheurs

February 15th-17th, 2016
School of Pharmacie, Lille, France

Iris Biotech GmbH will be present during the talks and supports the organisation with a booth at the Industrial Exhibition. We are pleased to get in personal contact with you.

Inexpensive & High Quality Guanylation Reagents

We now offer N,N'-Bis-Boc-N"-triflylguanidine, at both a very competitive price and our habitual high quality. Find out about the usefulness of this and our other guanylation reagents!