Homologization of natural amino acids

Several platforms are available to display the whole assortment of homo-amino acids, as well as the higher homologues β²-, β³-, their double substituted derivatives β^2,2,2-, β^3,3-, and corresponding γ-amino acids. Using e.g. via 4-benzyloxazolidin-2-one templates and using specific conformation of the chiral benzyl residue each conformation of a β²-analogue can precisely be addressed.

The variation and possibilities become even more diverse with GABA (γ-amino butyric acid) as scaffold. Our platform allows using any available amino acid as starting material and transform them into the corresponding Statine-analogue.

Templates of homo- β²-, β³-, and γ-amino acids and possible Statine analogues.

Examples of possible double substituted derivatives of β^2,2- and β^3,3-amino acids.