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Linkerology
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Conjugating Natural Products (3)
The potential of natural products of daily life, such as 6-shogaol from ginger (Zingiber officinale), can flourish if the active ingredient is conjugated to an appropriate carrier via Linkerology®.
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Functionalization of Carbon Materials by Linker Attachment
Allotropes of carbon show distinct characteristics in structure and e.g. electric and biophysiological properties. Discover how these materials can be further exploited by linker attachment!
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Functionalization of (Inert) Polymeric Surfaces
Plasma technology allows to equip inert polymers such as poly(ethylene) or polystyrene with functional groups like amine or carboxylate enabling further conjugations and applications. Read on!
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Conjugating Natural Products (2)
Infinite like the deep sea – marine natural products are an infinite source of (bio)active compounds. In this series we present how natural products can be conjugated to empower their inherent potential.
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Conjugating Natural Products (1)
From evolution to solution - natural products are an infinite source of (bio)active compounds. In this series we present how natural products can be conjugated to empower their inherent potential.
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Maleimide Crosslinkers
Maleimides provide versatile options for connecting payloads to proteins and other biomolecules. Discover how our bifunctional thiol reactive crosslinkers can support your project. Read on!
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PotM: Perfluorobiphenyl Building Blocks for Site-Selective Cysteine Conjugation
Herein, we present functionalized perfluorobiphenyl building blocks which can be used for site-selective π-clamp mediated cysteine conjugation. Read on for more details about this general method!
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Choose your Taste – Functionalized Halo/Snap/Clip Substrates
The HaloTag®, SNAP-Tag® and CLIP-TagTM represent versatile tools for the specific, covalent attachment of in principle any molecule of choice to a protein of interest. Discover our substrates!
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Temporary Activity Masking via Self-Immolative Linkage
(Bi)functional dioxoborolane and disulfide-based self-immolative linkers – mode of action and application examples for the detection of H2O2, for prodrug design, and reversible peptide cyclization.
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Linker Technologies for Sophisticated Bioconjugations
Linkers serve as versatile tools, e.g. during SPPS or for the sophisticated (self-immolative) conjugation of a potent small molecule to a carrier. Check out our selection of over 100 readily available linkers.
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