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Continue to Iris Biotech GmbHSend request to US distributorPublished on 16.04.2015
A set of new statin analogues, so called Super-Threonines, is available consisting of Fmoc protected L-enantiomers with all possible 4 stereoisomers of chiral centers in the side chain. They appear in nature as bridge building element in Pipecolidepsin A, a head-to-side-chain cyclodepsipeptide found in the marine sponge Homophymia lamellosa. This compound shows relevant cytotoxic activity in three human tumor cell lines (lung, colon, breast) and has unique structural features, with an abundance of non-proteinogenic residues, including several intriguing amino acids. (1)
Super-Threonines can be coupled in peptide synthesis with standard protocols (DCC/HOBt) without any protection of the OH group. Forming an ester with this OH group is more difficult than forming an amide bond. A route using symmetric anhydrides and DMAP with prolonged reaction times has been reported as a successful approach. (2)
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Super-Threonines