Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
USD
Quick contact
Please send me more information about
Aloc-L-Arg(Pbf)-OH
Chemical name: N-alpha-Allyloxycarbonyl-N'-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine // Synonyms: Aloc-Arg(Pbf)-OH, Alloc-Arg(Pbf)-OH, (S)-2-(allyloxycarbonylamino)-5-(3-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)guanidino)pentanoic acid, Alloc-L-Arg(Pbf)-OH
- Product code:AAA2030
- CAS No.:783371-61-9
- Formula:C23H34N4O7S
- Storage temperature:2-8°C
- Molecular weight:510.6 g/mol
- Purity :min. 98%
- Enantiomeric Purity:min. 99.7%
from $112.50
description
Reported for the synthesis of an Arg analogue of Teixobactin, where L-Arg (linear) replaced the L-allo-enduracididine (cyclic) residue as both of these building blocks are guanidine-based amino acids. The Aloc protecting group is fully compatible with Fmoc/tBu and Boc/Bzl strategies. N-Allyloxycarbonyl (Aloc) are widely used protecting groups, i.e. for amines and amino acids, as they are quantitatively and very rapidly converted to free amino compounds by palladium. The 2,2,4,6,7-pentamethyIdlhydrobenzofuran-5-sulfonyl group (Pbf) can be easily cleaved by trifluoroacetic acid (TFA).
references
Synthesis of a PNA-encoded cysteine protease inhibitor library; F. Debaene, L. Mejias, J. L. Harris, N. Winssinger; Tetrahedron 2004; 60(39): 8677-8690. https://doi.org/10.1016/j.tet.2004.05.107.
Synthesis and Biological Evaluation of a Teixobactin Analogue; Y. E. Jad, G. A. Acosta, T. Naicker, M. Ramtahal, A. El-Faham, T. Govender, H. G. Kruger, B. G. de la Torre, F. Albericio. Org. Lett. 2015; 17(24): 6182-6185. https://doi.org/10.1021/acs.orglett.5b03176.
Preparation of compounds having amino acid residue or peptide residue and process for producing the same; H. Ikeda, M. Tonosaki; PCT Int. Appl. Patent 2006; WO2006115230 A1.
* Disclaimer
Prices are excl. tax, excl. shipping.
We refer to our general terms and conditions.
All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
Do you need further information about this product?
get in contact
We found other products you might like!
