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Fmoc-4-AMCHC-OH
Chemical name: trans-4-(9-Fluorenylmethyloxycarbonylaminomethyl)-cyclohexanoic acid // Synonyms: Fmoc-tranexamic acid, trans-4-(Fmoc-aminomethyl)cyclohexanecarboxylic acid, Fmoc-4-Amc-OH, Fmoc-Trx-OH
- Product code:FAA1647
- CAS No.:167690-53-1
- Formula:C23H25NO4
- Storage temperature:2-8°C
- Molecular weight:379.46 g/mol
- Purity :min. 99%
from $68.75
description
Fmoc-AMCHC is used as a linker in solid-phase peptide synthesis to construct various biologically active conjugates. This fragment is present in many Antibody-Drug Conjugates (Kadcyla®, IMMU-132).
references
Benesova, Martina; Bauder-Wuest, Ulrike; Schaefer, Martin; Klika, Karel D.; Mier, Walter; Haberkorn, Uwe; Kopka, Klaus; Eder, Matthias; J. Med. Chem. 2016; 59(5): 1761-1775. DOI:10.1021/acs.jmedchem.5b01210;
Behrens et al PCT Int. Appl. (2011), WO 2011089255 A1.
Zhu et al PCT Int. Appl. (2019), WO 2019011166 A1.
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