Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
USD
Quick contact
Please send me more information about
Fmoc-Dbz-OH
Chemical name: 3-[(9-Fluorenylmethyloxycarbonyl)amino]-4-amino-benzoic acid // Synonyms: 3-Fmoc-4-diaminobenzoic acid
- Product code:FAA3165
- CAS No.:1071446-05-3
- Formula:C22H18N2O4
- Storage temperature:2-8°C
- Molecular weight:374.39 g/mol
- Purity :min. 97%
from $157.50
description
Dbz is a novel linker for the synthesis of peptide thioesters by Fmoc SPPS . After Fmoc removal the resin is being acylated with the first amino acid and then peptide synthesis is carried out. Following chain assembly the resin is being activated by treatment with p-nitrophenyl chloroformate. TFA cleaves the fully deprotected peptide benzimidazolinone which can be converted to a thioester with aryl thiol or used directly in native chemical ligation.
references
A Reversible Protection Strategy To Improve Fmoc-SPPS of Peptide Thioesters by the N-Acylurea Approach; Santosh K. Mahto, Cecil J. Howard, John C. Shimko, and Jennifer J. Ottesen;
ChemBioChem 2011; 12: 2488-2494. DOI: 10.1002/cbic.201100472.
An efficient Fmoc-SPPS approach for the generation of thioester peptide precursors for use in native chemical ligation; Blanco-Canosa, J. B. & Dawson, P. E.; Angew. Chem. Int. Ed.
2008; 47: 6851-6855.
Z. Harpaz, et al.; ChemBioChem 2010; 11: 1232.
B. L. Pentelute, et al., Chem. Biol. 2010; 5: 359.
T. K. Tiefenbrunn, et al.; Pept. Sci. 2010; 94: 405.
* Disclaimer
We refer to our general terms and conditions.
All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
Do you need further information about this product?
get in contact
Brochures & Flyers
We found other products you might like!
