Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
USD
Quick contact
Please send me more information about
Fmoc-Dbz(o-NO2)-OH
Chemical name: 4-(Fmoc-amino)-3-Nitro-benzoic acid // Synonyms: 4-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-nitro-benzoic acid
- Product code:FAA3169
- CAS No.:1342864-48-5
- Formula:C22H16N2O6
- Storage temperature:2-8°C
- Molecular weight:404.37 g/mol
from $375.00
description
Typically, 3,4-diaminobenzoid acid (Dbz) is used for the efficient synthesis of peptide thioesters by Fmoc chemistry solid phase peptide synthesis. Optionally, a solubility tag can be attached to the C-terminus. Protection of the free amine is required to prevent over-acylation observed using the typical Dawson reagent. The 4-amino-3-nitrobenzoic acid linker was developed for microwave-assisted synthesis. Dbz(NO2) can easily be converted into the Dbz linker by on-resin reduction with SnCl2 after peptide synthesis.
Eventhough, epimerization of the C-terminal amino acid limits the use of the nitro derivative, it prevents side reactions which occur when Dbz or Dbz(Alloc) linkers are used during microwave-assisted synthesis, e.g. of Gly-rich peptides.
references
Preparation of Peptide o-Aminoanilides Using a Modified Dawson’s Linker for Microwave-Assisted Peptide Synthesis; S. Tsuda, T. Uemura, M. Mochizuki, H. Nishio, T. Yoshiya; Synlett 2017; 28: 1956-1960. https://doi.org/10.1055/s-0036-1588862.
* Disclaimer
We refer to our general terms and conditions.
All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
Do you need further information about this product?
get in contact
Brochures & Flyers
We found other products you might like!
