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Propargyl-PEG(5)-COOH
Chemical name: 4,7,10,13,16-pentaoxanonadec-18-ynoic acid // Synonyms: Alkyne-PEG(5)-COOH, Alkyne-PEG(5)-acid, Propargyl-PEG(5)-acid
- Product code:PEG8170
- CAS No.:1245823-51-1
- Formula:C14H24O7
- Storage temperature:-20°C
- Molecular weight:304.34 g/mol
from $187.50
description
Heterobifunctional, PEGylated crosslinker bearing a carboxylic acid moiety and a propargyl group, which can be reacted with azide-containing compounds using Click chemistry. The hydrophilic PEG crosslinker facilitates solubility in biological applications.
references
Semisynthetic Analogs of the Antibiotic Fidaxomicin – Design, Synthesis, and Biological Evaluation; A. Dorst, R. Berg, C. G. W. Gertzen, D. Schäfle, K. Zerbe, M. Gwerder, S. D. Schnell, P. Sander, H. Gohlke, K. Gademann; ACS Med. Chem. Lett. 2020; 11(12): 2414-2420. https://doi.org/10.1021/acsmedchemlett.0c00381.
Improved Inhibition of Tumor Growth by Diabody-Drug Conjugates via Half-Life Extension; Q. Li, A. Barrett, B. Vijayakrishnan, A. Tiberghien, R. Beard, K. W. Rickert, K. L. Allen, R. J. Christie, M. Marelli, J. Harper, P. Howard, H. Wu, W. F. Dall‘Acqua, P. Tsui, C. Gao, M. J. Borrok; Bioconjugate Chem. 2019; 30(4): 1232-1243. https://doi.org/10.1021/acs.bioconjchem.9b00170.
Straightforward Glycoengineering Approach to Site-Specific Antibody-Pyrrolobenzodiazepine Conjugates; P. Thompson, E. Ezeadi, I. Hutchinson, R. Fleming, B. Bezabeh, J. Lin, S. Mao, C. Chen, L. Masterson, H. Zhong, D. Toader, P. Howard, H. Wu, C. Gao, N. Dimasi; ACS Med. Chem. Lett. 2016; 7(11): 1005-1008. https://doi.org/10.1021/acsmedchemlett.6b00278.
Site-Specific Antibody Labeling by Covalent Photoconjugation of Z Domains Functionalized for Alkyne-Azide Cycloaddition Reactions; A. Perols, M. A. Famme, A. E. Karlström; ChemBioChem 2015; 16(17): 2522-2529. https://doi.org/10.1002/cbic.201500300.
Enzyme-free translation of DNA into sequence-defined synthetic polymers structurally unrelated to nucleic acids; J. Niu, R. Hili, D. R. Liu; Nat. Chem. 2013; 5(4): 282-292. https://doi.org/10.1038/nchem.1577.
“Clickable”, polymerized liposomes as a versatile and stable platform for rapid optimization of their peripheral compositions; A. Kumar, U. J. Erasquin, G. Qin, K. Li, C. Cai; Chem. Commun. 2010; 46: 5746-5749. https://doi.org/10.1039/C0CC00784F.
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