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DBCO-NHS
Chemical name: Dibenzoazacyclooctyne-carboxylic acid succinimidyl ester // Synonyms: DBCO-C6-NHS ester, ADIBO-NHS ester, Azadibenzocyclooctyne-carboxylic acid succinimidyl ester, 6-oxo-6-(azadibenzocyclooctyn-1-yl)hexanoic acid succinimidyl ester
- Product code:RL-2440
- CAS No.:1384870-47-6
- Formula:C25H22N2O5
- Storage temperature:-20°C
- Molecular weight:430.45 g/mol
from $525.00
description
Cyclooctyne linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with azides and tetrazines. The carboxylic acid function can be used to form amid bonds with amines.
references
Simon et al.; Facile Double-Functionalization of Designed Ankyrin Repeat Proteins using Click and Thiol Chemistries. Bioconjugate Chem. 2012; 23(2): 279.
Zeng et al.; 64Cu Core-Labeled Nanoparticles with High Specific Activity via Metal-Free Click Chemistry. ACS Nano. 2012; 6(6): 5209.
Arumugam et al.; [18F]Azadibenzocyclooctyne ([18F]ADIBO): A biocompatible radioactive labeling synthon for peptides using catalyst free [3+2] cycloaddition. Bioorg. Med. Chem. Lett. 2011; 21: 6987.
Campbell-Verduyn et al.; Strain-Promoted Copper-Free Click Chemistry for 18F Radiolabeling of Bombesin. Angew. Chem. Int. Ed. 2011; 50: 11117.
Debets et al.; Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition. Chem. Commun. 2010: 46: 97.
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