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Biotin-AEEA-OPhOMe
Chemical name: 2-(2-(2-(Biotinamido)ethoxy)ethoxy)acetic acid 4-methoxyphenyl ester // Synonyms: 4-methoxyphenyl 2-(2-(2-(Biotinamido)ethoxy)ethoxy)acetate, 4-methoxyphenyl 2-(2-(2-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethoxy)ethoxy)acetate
- Product code:RL-3100
- CAS No.:2546513-67-9
- Formula:C23H33N3O7S
- Storage temperature:-20°C
- Molecular weight:495.59 g/mol
- Purity :min. 95%
from $731.25
description
Methodology for highly selective N-terminal chemical acylation of expressed proteins. This 4-methoxyphenyl ester adds selectively to Gly-His-tags of proteins, while it does not react with epsilon amino functions of surface accessible lysines. Therefore, it expresses a unique possibility to label proteins regiospecific at the Gly-His tag position, enabling a wide application field in chemical biology and for biopharmaceuticals.
references
Selective N-terminal acylation of peptides and proteins with a Gly-His tag sequence; Manuel C. Martos-Maldonado, Christian T. Hjuler, Kasper K. Sørensen, Mikkel B. Thygesen, Jakob E. Rasmussen, Klaus Villadsen, Søren R. Midtgaard, Stefan Kol, Sanne Schoffelen, and Knud J. Jensen; Nature Communications 2018; 9: 3307. DOI: 10.1038/s41467-018-05695-3
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