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ICG-tyramide
Chemical name: Indocyanine green-tyramide // Synonyms: ICG-phenol, Indocyanine green-phenol,4-(2-((1E,3E,5E,7E)-7-(3-(6-((4-hydroxyphenethyl)amino)-6-oxohexyl)-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)hepta-1,3,5-trien-1-yl)-1,1-dimethyl-1H-b enzo[e]indol-3-ium-3-yl)butane-1-sulfonate
- Product code:RL-3350
- Formula:C53H59N3O5S
- Molecular weight:850.12 g/mol
from $312.50
description
Indocyanine green (ICG) is a near-infrared fluorescence imaging dye. Absorption maximum is at 800 nm and there is slight absorption in the visible range, which results in low auto-fluorescence and tissue absorbance. Emission maximum is at 810 nm.
The phenol group binds specifically to tyrosine on activation with HRP. It can be used in many applications including immunohistochemistry, in situ hybridization, electron microscopy, ELISA, and others.
ICG has been approved by the FDA and has been found in numerous applications in therapeutics and diagnostics, like: detection of solid tumors, localization of lymphnodes, visualization of retinal and choroidal vasculature, angiography during reconstructive surgery. ICG can be used as imaging dye and as a hyperthermia agent.
references
The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery. Boudewijn E. Schaafsma MD, J. Sven D. Mieog MD, Merlijn Hutteman MSc, Joost R. van der Vorst MD, Peter J.K. Kuppen PhD, Clemens W.G.M. Lwik PhD, John V. Frangioni MD, PhD, Cornelis J.H. van de Velde MD, PhD, Alexander L. Vahrmeijer MD, PhD; Surg. Oncol. 2011; 104: 323-332. DOI: 10.1002/jso.21943.
Degradation kinetics of indocyanine green in aqueous solution. Vishal Saxena, Mostafa Sadoqi, Jun Shao; J. Pharm. Sci. 2003; 92: 2090-2097. DOI: 10.1002/jps.10470.
Stability assessment of indocyanine green within dextran-coated mesocapsules by absor- bance spectroscopy. Mohammad Abbas Yaseen; Jie Yu; Michael S. Wong; Bahman Anvari; Journal of Biomedical Optics 2007; 12(6): 064031. DOI:10.1117/1.2821423.
H-Type Dimer Formation of Fluorophores: A Mechanism of Activatable In Vivo Optical Molecular Imaging. Mikako Ogawa, Nobuyuki Kosaka, Peter L. Choyke and Hisataka Kobayashi; ACS Chem. Biol. 2009; 4(7): 535-546. DOI: 10.1021/cb900089j.
In vivo Molecular Imaging of Cancer with a Quenching Near-Infrared Florescent Probe Using Conjugates of Monoclonal Antibodies and Indocyanine Green. Mikako Ogawa, Nobuyuki Kosaka, Peter L. Choyke, and Hisataka Kobayashi; Cancer Res. 2009; 69(4): 1268-1272. DOI: 10.1158/0008-5472.
H.W. Rhee, P. Zou, N.D. Udeshi, J.D. Martell, V.K. Mootha, S.A. Carr, A.Y. Ting; Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging; Science 2013; 339: 1328-31. www.sciencemag.org/cgi/content/full/science.1230593/DC1 . DOI: 10.1126/science.1230593.
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