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ICG-SNAP
Chemical name: 4-(2-((1E,3E,5E,7E)-7-(3-(6-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)amino)-6-oxohexyl)-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)hepta-1,3,5-trien-1-yl)-1,1-dimethyl-1H-benzo[e]indo l-3-ium-3-yl)butane-1-sulfonate // Synonyms: ICG-BG, ICG-Benzylguanine, Indocyanine green benzylguanine
- Product code:RL-3830
- Formula:C58H62N8O5S
- Molecular weight:983.25 g/mol
from $375.00
description
Indocyanine green (ICG) is a near-infrared fluorescence imaging dye. Absorption maximum is at 800 nm and there is slight absorption in the visible range, which results in low auto-fluorescence and tissue absorbance. Emission maximum is at 810 nm. ICG has been approved by the FDA.
RL-3830 is an ICG conjugated benzylguanine (BG). The BG moiety reacts specifically and rapidly with the so-called SNAP-tag, a polypeptide protein tag, allowing irreversible and covalent labeling of SNAP fusion proteins with ICG.
references
The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery. Boudewijn E. Schaafsma MD, J. Sven D. Mieog MD, Merlijn Hutteman MSc, Joost R. van der Vorst MD, Peter J.K. Kuppen PhD, Clemens W.G.M. Lwik PhD, John V. Frangioni MD, PhD, Cornelis J.H. van de Velde MD, PhD, Alexander L. Vahrmeijer MD, PhD; Surg. Oncol. 2011; 104: 323-332. https://doi.org/10.1002/jso.21943.
Degradation kinetics of indocyanine green in aqueous solution. Vishal Saxena, Mostafa Sadoqi, Jun Shao; J. Pharm. Sci. 2003; 92: 2090-2097. https://doi.org/10.1002/jps.10470.
Stability assessment of indocyanine green within dextran-coated mesocapsules by absor- bance spectroscopy. Mohammad Abbas Yaseen; Jie Yu; Michael S. Wong; Bahman Anvari; Journal of Biomedical Optics 2007; 12(6): 064031. https://doi.org/10.1117/1.2821423.
Imaging proteins inside cells with fluorescent tags; G. Crivat, J. W. Taraska; Trends Biotechnol 2012; 30(1): 8-16. https://doi.org/10.1016/j.tibtech.2011.08.002.
Directed Evolution of O6-Alkylguanine-DNA Alkyltransferase for Efficient Labling of Fusion Proteins with Small Molecules in Vivo; A. Juillerat, T. Gronemeyer, A. Keppler, S. Gendreizig, H. Pick, H.Vogel, K. Johnsson; Cell Chem. Biol. 2003; 10(4): 313-317. https://doi.org/10.1016/S1074-5521(03)00068-1.
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