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5HP2O-(CH2)4-NHS
Chemical name: 2,5-dioxopyrrolidin-1-yl 5-(2-hydroxy-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoate
- Product code:RL-8680
- Formula:C14H18N2O6
- Storage temperature:2-8°C
- Molecular weight:310.31 g/mol
from $525.00
description
5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones (5HP2Os) are next-generation thiol-reactive conjugating groups superior in reactivity and stability to conventional maleimides. Maleimides are prone to hydrolysis, retro-Michael reactions and/or thiol exchange reactions, resulting in antibody and protein conjugates with poor stability. 5HP2O linkers are highly selective for cysteines, yielding conjugates with superior stability.
references
5-Hydroxy-pyrrolone based building blocks as maleimide alternatives for protein bioconjugation and single-site multi-functionalization; E. De Geyter, E. Antonatou, D. Kalaitzakis, S. Smolen, A. Iyer, L. Tack, E. Ongenae, G. Vassilikogiannakis, A. Madder; Chem. Sci. 2021; 12: 5246-5252. https://doi.org/10.1039/d0sc05881e
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Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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