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Fmoc-L-Lys(Pentynoyl-DIM)-OH
Nom chimique: N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-[1-(4,4-dimethyl-2,6- dioxocyclohexylidene)pent-4-yn-1-yl]-L-lysine // Synonymes: Fmoc-Lys(Pentynoyl-DIM), (2S)-6-{[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)pent-4-yn-1-yl]amino}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoic acid,Fmoc-Lys(Pentynoyl-DIM)-OH
- n° Art.:FAA8115
- n° CAS:2408993-33-7
- Formule:C34H38N2O6
- Storage temperature:2-8°C
- Masse moléculaire:570,69 g/mol
- Pureté:min. 98%
- Pureté Énantiomérique:min. 99,7%
from 180,00 €
description
Used as a SPPS building block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution.
references
Synthesis of hydrophobic insulin-based peptides using a helping hand strategy; M. M. Disotuar, M. E. Petersen, J. M. Nogueira, M. S. Kay and D. H. Chou; Org Biomol Chem 2019; 17: 1703-1708. https://doi.org/10.1039/c8ob01212a
A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis; M. T. Jacobsen, M. E. Petersen, X. Ye, M. Galibert, G. H. Lorimer, V. Aucagne and M. S. Kay; J Am Chem Soc 2016; 138: 11775-82. https://doi.org/10.1021/jacs.6b05719
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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