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Fmoc-D-Lys(Ns)-OH
Nom chimique: N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-nosyl-D-lysine // Synonymes: N-alpha-Fmoc-N-epsilon-nosyl-D-lysine, N-alpha-Fmoc-N-epsilon-(2-nitrobenzenesulfonyl)-D-lysine,(R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(2-nitrophenylsulfonamido)hexanoic acid
- n° Art.:FAA4210
- n° CAS:2250437-39-7
- Formule:C27H27N3O8S
- Storage temperature:2-8°C
- Masse moléculaire:553,58 g/mol
- Pureté:min. 98%
- Pureté Énantiomérique:min. 99,7%
from 115,00 €
description
Building block with side protection orthogonal to Fmoc/tBu strategy. Can be used for side specific derivatization, for example for TFA mediated in situ cyclization, which is taking advantage of intermediate aspartamide formation.
references
A Tandem In Situ Peptide Cyclization through Trifluoroacetic Acid Cleavage; Koushik Chandra, Tapta Kanchan Roy, Deborah E. Shalev, Abraham Loyter, Chaim Gilon, R. Benny Gerber, and Assaf Friedler; Angew. Chem. Int. Ed. 2014; 53: 9450-9455. DOI: 10.1002/anie.201402789.
Luca Monfregola, Marilisa Leone, Enrica Calce, Stefania De Luca; Postsynthetic Modification of Peptides via Chemoselective N-Alkylation of Their Side Chains; Org. Lett. 2012; 14(7): 1664-1667; doi 10.1021/ol300437w.
Stefania De Luca, Raffaella Della Moglie, Antonia De Capua, Giancarlo Morelli; New synthetic strategy for o-NBS protected amino acids and their use in synthesis of mono-benzylated peptides; Tetrahedron Lett. 2005; 46: 6637-6640; doi:10.1016/j.tetlet.2005.07.154.
Luca Monfregola, Stefania De Luca; Synthetic strategy for side chain mono-N-alkylation of Fmoc-amino acids promoted by molecular sieves; Amino Acids 2001; 41(4): 981-990; doi 10.1007/s00726-010-0798-6.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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