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Fmoc-L-Lys(N3-Aca-DIM)-OH
Nom chimique: N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-[6-azido-1-(4,4-dimethyl-2,6- dioxocyclohexylidene)hexyl]-L-lysine // Synonymes: Fmoc-Lys(N3-Aca-DIM), (2S)-6-{[6-azido-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)hexyl]amino}-2-({[(9H-fluoren-9- yl)methoxy]carbonyl}amino)hexanoic acid,Fmoc-Lysine(Dimedone-azidocaproyl), N2-(((9H- fluoren-9-yl)methoxy)carbonyl)-N6-(6-azido-1-(4,4-
- n° Art.:FAA8145
- n° CAS:2408993-39-3
- Formule:C35H43N5O6
- Storage temperature:-20°C
- Masse moléculaire:629,76 g/mol
- Pureté:min. 99%
- Pureté Énantiomérique:min. 99,7%
from 120,00 €
description
Used as a SPPS building-block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution.
references
A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis. Michael T. Jacobsen, Mark E. Petersen, Xiang Ye, Mathieu Galibert, George H. Lorimer, Vincent Aucagne, Michael S. Kay; J. Am. Chem. Soc. 2016; 138(36): 11775-11782. DOI: 10.1021/jacs.6b05719
Synthesis of hydrophobic insulin-based peptides using a helping hand strategy. Maria M. Disotuar, Mark E. Petersen, Jason M. Nogueira, Michael S. Kay, Danny Hung-Chieh Chou; Org. Biomol. Chem. 2019; 17: 1703-1708. DOI: 10.1039/C8OB01212A
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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