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Biotin-aniline
Nom chimique: N-(4-aminophenethyl)-biotinamide // Synonymes: Btn-An, Biot-aniline, N-[2-(4-aminophenyl)ethyl]hexahydro-2-oxo-(3aS,4S,6aR)-1H-thieno[3,4-d]imidazole-4-pentanamide,N-(4-aminophenethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl )pentanamide, 5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-t
- n° Art.:LS-3970
- n° CAS:769933-15-5
- Formule:C18H26N4O2S
- Storage temperature:-20°C
- Masse moléculaire:362,49 g/mol
- Pureté:min. 98%
from 170,00 €
description
Biotin-aniline labelling with APEX2 can capture all 13 mitochondrial messenger RNAs while leaving all cyrtoplasmic RNAs untouched. APEX2-mediated Btn-An labeling of RNA is thus a promising method for mapping the subcellular transcriptome, which could shed light on their functions in cell physiology. Hence it provides an alternative methodology to the common Biotin-phenol labelling.
references
Expanding APEX2 Substrates for Spatial-specific Labeling of Nucleic Acids and Proteins in Living Cells; Y. Zhou, G. Wang, P. Wang, Z. Li, T. Yue, J. Wang, P. Zou; Angew. Chem. Int. Ed. 2019; 58(34): 1763-11767. https://doi.org/10.1002/anie.201905949.
Spatiotemporal profiling of cytosolic signaling complexes in living cells by selective proximity proteomics; M. Ke, X. Yuan, A. He, P. Yu, W. Chen, Y. Shi, T. Hunter, P. Zou, R. Tian; Nat. Commun. 2021; 12: 71. https://doi.org/10.1038/s41467-020-20367-x.
Mapping spatial transcriptome with light-activated proximity-dependent RNA labeling; P. Wang, W. Tang, Z. Li, Z. Zou, Y. Zhou, R. Li, T. Xion, J. Wang, P. Zou; Nat. Chem. Biol. 2019; 15(11): 1110-1119. https://doi.org/10.1038/s41589-019-0368-5.
Fabrication and characterization of heparin functionalized membrane-mimetic assemblies; P.-Y. Tseng, S. M. Rele, X.-L. Sun, E. L. Chaikof; Biomaterials 2006; 27(12): 2627-2636. https://doi.org/10.1016/j.biomaterials.2005.10.032.
Quantification of streptavidin adsorption in microtitration wells; L. Välimaa, K. Pettersson, J. Rosenberg, M. Karp, T. Lövgren; Anal. Biochem. 2004; 331(2): 376-384. https://doi.org/10.1016/j.ab.2004.04.003.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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