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Photo-Trimethyl-Lock
Nom chimique: 3-(2-Nitroveratryl-4,6-dimethylphenyl)-3-methylbutyric acid
- n° Art.:RL-2970
- n° CAS:2095134-25-9
- Formule:C22H27NO7
- Storage temperature:2-8°C
- Masse moléculaire:417,45 g/mol
from Sur demande
description
The trimethyl-lock concept is a new methodology to mask and inactivate active compounds and activate them by specific conditions. The traceless release of compounds protected with this TML derivative can be triggered by photolytic cleavage.
A wide range of applications already has been published, like prodrug and drug release, use as self immolative spacer or in biomolecular imaging.
references
Syntheses and kinetic studies of cyclisation-based self-immolative spacers; Steve Huvelle, Ahmed Alouane, Thomas Le Saux, Ludovic Jullien, and Frédéric Schmidt; Org. Biomol. Chem.
2017; 15: 3435-3443. DOI: 10.1039/c7ob00121e
Trimethyl lock: a trigger for molecular release in chemistry, biology, and pharmacology; Michael N. Levine and Ronald T. Raines; Chem. Sci. 2012; 3: 2412-2420. DOI:
10.1039/c2sc20536j
Syntheses and kinetic studies of cyclisation-based self-immolative spacers; Steve Huvelle, Ahmed Alouane, Thomas Le Saux, Ludovic Jullien and Frédéric Schmidt; Org. Biomol. Chem.
2017; 15: 3435-3443. DOI: 10.1039/C7OB00121E
Self-Immolative Spacers: Kinetic Aspects, Structure-Property Relationships, and Applications; Ahmed Alouane, Raphaël Labruère, Thomas Le Saux, Frédéric Schmidt, and Ludovic
Jullien; Angew. Chem. Int. Ed. 2015; 54: 7492-7509. DOI: 10.1002/anie.201500088
Fluorogenic Label for Biomolecular Imaging; Luke D. Lavis, Tzu-Yuan Chao, and Ronald T. Raines; ACS Chem. Biol. 2006; 1(4): 252-260. DOI: 10.1021/cb600132m
Prodrug Strategies Based on Intramolecular Cyclization Reactions; Daxian Shan, Michalis G. Nicolaou, Ronald T. Borchardt, and Binghe Wang; J. Pharm. Sci. 1997; 86(7): 765-767.
DOI: S0022-3549(97)00069-5
Drug Delivery Systems Based on Trimethyl Lock Lactonization: Poly(ethylene glycol) Prodrugs of Amino-Containing Compounds; Richard B. Greenwald, Yun H. Choe, Charles D. Conover,
Kwok Shum, Dechun Wu, and Maksim Royzen; J. Med. Chem. 2000; 43: 475-487. DOI: 10.1021/jm990498j
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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