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Biotin-Dde
Nom chimique: 2-(1-hydroxy-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentylidene)-5,5-dimethylcyclohexane-1,3-dione
- n° Art.:LS-4020
- n° CAS:194038-08-9
- Formule:C18H26N2O4S
- Storage temperature:-20°C
- Masse moléculaire:366,48 g/mol
from 125,00 €
description
This cleavable linker is highly valuable for usage in protein enrichment and other applications. A linker based on the Dde protecting group leads to efficient release of targets under mild aqueous buffered conditions with 2% hydrazine.
references
Cleavable trifunctional biotin reagents for protein labelling, capture and release; Y. Yang and S. H. Verhelst; Chem Commun (Camb) 2013; 49: 5366-8. https://doi.org/10.1039/c3cc42076k
Versatile Dde-based primary amine linkers for solid phase synthesis; S. R. Chhabra, A. N. Khan, B. W. Bycroft; Tetrahedron Lett. 1998; 39: 3585-3588. https://doi.org/10.1016/S0004-4039(98)00555-3
Mapping the Binding Site of BMS-708163 on gamma-Secretase with Cleavable Photoprobes; N. Gertsik, C. W. Am Ende, K. F. Geoghegan, C. Nguyen, P. Mukherjee, S. Mente, U. Seneviratne, D. S. Johnson and Y. M. Li; Cell Chem Biol 2017; 24: 3-8. https://doi.org/10.1016/j.chembiol.2016.12.006
Transient affinity tags based on the Dde protection/deprotection strategy: Synthesis and application of 2-biotinyl-and 2-hexanoyldimedone; B. Kellam, W. C. Chan, S. R. Chhabra, B. W. Bycroft; Tetrahedron Lett. 1997; 38(30): 5391-5394. https://doi.org/10.1016/S0040-4039(97)01180-5
Comprehensive mapping of O-GlcNAc modification sites using a chemically cleavable tag; M. E. Griffin, E. H. Jensen, D. E. Mason, C. L. Jenkins, S. E. Stone, E. C. Peters and L. C. Hsieh-Wilson; Mol. BioSyst. 2016; 12: 1756-1759. https://doi.org/10.1039/C6MB00138F
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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