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Fmoc-L-Tyr(tBu)-MPPA
Nom chimique: N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-t-butyl-L-tyrosine-3-(4-oxymethylphenoxy)propionic acid // Synonymes: (S)-3-(4-(((2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butoxy)phenyl)propanoyl)oxy)methyl)phenoxy)propanoic acid,O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-tyrosine [ 4-(2-carboxyethoxy)phenyl]methyl ester, Fmoc-Tyr(t
- n° Art.:LW01902
- n° CAS:864876-98-2
- Formule:C38H39NO8
- Storage temperature:2-8°C
- Masse moléculaire:637,73 g/mol
from 95,00 €
description
This Fmoc-amino acid-MPPA linker serves as precursor for the linkage to e.g. aminomethyl supports by standard coupling procedures. By this method, a low (max 0.5%) and reproducible epimerization level of the C-terminal amino acid in your peptide is guaranteed.
references
Improved approach for anchoring Nalpha-9-fluorenylmethyloxycarbonylamino acids as p-alkoxybenzyl esters in solid-phase peptide synthesis; F. Albericio, G. Barany; Int. J. Peptide. Protein. Res. 1985; 26(1): 92-97. https://doi.org/10.1111/j.1399-3011.1985.tb03182.x.
Amino acid derivatives used as agents bonding to a solid support; NeoMPS S.A. 2005; French Patent Application FR 0402973, International Patent Application WO2005/095332.
Molecular Signature for Receptor Engagement in the Metabolic Peptide Hormone Amylin; R. L. Bower, L. Yule, T. A. Rees, G. Deganutti, E. R. Hendrikse, P. W. R. Harris, R. Kowalczyk, Z. Ridgway, A. G. Wong, K. Swierkula, D. P. Raleigh, A. A. Pioszak, M. A. Brimble, C. A. Reynolds, C. S. Walker, D. L. Hay; ACS Pharmacol Transl. Sci. 2018; 1(1): 32-49. https://doi.org/10.1021/acsptsci.8b00002.
Structure activity relationship study on the peptide hormone preptin, a novel bone-anabolic agent for the treatment of osteoporosis; Z. Amso, R. Kowalczyk, M. Watson, Y.-E. Park, K. E. Callon, D. S. Musson, J. Cornish, M. A. Brimble; Org. Biomol. Chem. 2016; 14: 9225-9238. https://doi.org/10.1039/C6OB01455K.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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