Fmoc-L-Phe(4-CH2-N3)-OH

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-4-azidomethyl-L-phenylalanine // Synonyms: Fmoc-Phe(4-CH2-N3)-OH, Fmoc-p-azidomethyl-L-phenylalanine, Fmoc-para-methylazido-L-phenylalanine, Fmoc-para-azidomethyl-L-phenylalanine, Fmoc-pN3CH2Phe, Fmoc-pAMF,Fmoc-4-(azidomethyl)-L-phenylalanin e

  • Product code:FAA7740
  • CAS No.:2375587-79-2
  • Storage temperature:2-8°C
  • Formula:C25H22N4O4
  • Molecular weight:442.47 g/mol
  • Purity :min. 98%
  • Enantiomeric Purity:min. 99,7%

from €120.00

Grouped product items
Qty Packing unit Price SKU Availability
250 mg
€120.00
FAA7740.0250
<10 business days
500 mg
€220.00
FAA7740.0500
<10 business days
1 g
€300.00
FAA7740.0001
<10 business days
5 g
€1,200.00
FAA7740.0005
<10 business days
Safety Data Sheets
description

This material is used in antibody drug conjugates as a superior SPAAC reaction partner in comparison to H-Phe(4-N3). It can serve as a vibrational reporter of local protein environments after genetic incorporation into proteins. 

references

Production of Site-Specific Antibody–Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System; Erik S. Zimmerman, Tyler H. Heibeck, Avinash Gill, Xiaofan Li, Christopher J. Murray, Mary Rose Madlansacay, Cuong Tran, Nathan T. Uter, Gang Yin, Patrick J. Rivers, Alice Y. Yam, Willie D. Wang, Alexander R. Steiner, Sunil U. Bajad, Kalyani Penta, Wenjin Yang, Trevor J. Hallam, Christopher D. Thanos, Aaron K. Sato; Bioconjugate Chem. 2014; 25(2): 351-361. DOI:10.1021/bc400490z.

Sensitive, Site-Specific, and Stable Vibrational Probe of Local Protein Environments: 4-Azidomethyl-l-Phenylalanine; Christopher G. Bazewicz, Melanie T. Liskov, Kevin J. Hines, Scott H. Brewer;

J. Phys. Chem. B 2013; 117(30): 8987-8993. DOI:10.1021/jp4052598;

Methods of using anti-cd74 antibodies and antibody conjugates in treatment of t-cell lymphoma; Molina, Arturo; PCT Int. Appl. 2019; WO 2019023316 A1.

 

Do you need further information about this product?

get in contact

Quick contact

Please send me more information about

We found other products you might like!