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Fmoc-L-Phe(4-NH-Poc)-OH
Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-4-propargyloxycarbonylamino-L-phenylalanine // Synonyms: Fmoc-Phe(4-NH-Poc)-OH, Fmoc-L-Aph(Poc)-OH, Fmoc-4Aph(Poc), Fmoc-L-4Aph(Poc)-OH, Fmoc-L-4-Aph(Poc)-OH, Fmoc-p-amino-Phe(Poc)-OH, Fmoc-L-Phe(4-NH-Poc)-OH, Fmoc-4Aph(Pryoc),Fmoc-L-4Aph(Pryoc)-OH, Fmoc- L-4-Aph(Pryoc)-OH, Fmoc-p-amino-Phe(Pryoc)-OH
- Product code:FAA7720
- CAS No.:2576508-07-9
- Formula:C28H24N2O6
- Storage temperature:2-8°C
- Molecular weight:484.5 g/mol
- Purity :min. 98%
- Enantiomeric Purity:min. 99,7%
from €108.00
description
Used as an orthogonally protected building block in solid-phase peptide synthesis. Poc-group can be further modified using Click-chemistry.
references
Bioorthogonal Catalysis: A General Method To Evaluate Metal-Catalyzed Reactions in Real Time in Living Systems Using a Cellular Luciferase Reporter System; H. T. Hsu, B. M. Trantow, R. M. Waymouth and P. A. Wender; Bioconjug Chem 2016; 27: 376-82. https://doi.org/10.1021/acs.bioconjchem.5b00469
N-alkynyl derivatives of 5-fluorouracil: susceptibility to palladium-mediated dealkylation and toxigenicity in cancer cell culture; J. T. Weiss, C. Fraser, B. Rubio-Ruiz, S. H. Myers, R. Crispin, J. C. Dawson, V. G. Brunton, E. E. Patton, N. O. Carragher and A. Unciti-Broceta; Front Chem 2014; 2: 56. https://doi.org/10.3389/fchem.2014.00056
Palladium-triggered deprotection chemistry for protein activation in living cells; J. Li, J. Yu, J. Zhao, J. Wang, S. Zheng, S. Lin, L. Chen, M. Yang, S. Jia, X. Zhang and P. R. Chen; Nat Chem 2014; 6: 352-61. https://doi.org/10.1038/nchem.1887
Propargyloxycarbonyl and propargyl groups for novel protection of amino, hydroxy, and carboxy functions; Y. Fukase, K. Fukase and S. Kusumoto; Tetrahedron Letters 1999; 40: 1169-1170. https://doi.org/10.1016/s0040-4039(98)02555-6
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