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Biotin Tyramide Reagents for Tyrosine-/Protein-Biotinylation

Tyramine compounds are converted to highly reactive radicals by horseradish peroxidase in presence of H2O2 which preferentially react with surface exposed tyrosines. Biotin Tyramide and Biotin-PEG-Tyramide therefore are ideal reagents used for tyrosine-/protein-biotinylation.

Bis-Mal-Lysine

Bis Thiol & Amine reactive PEGylated Cross-Linker which has been used for enhanced receptor binding, for the design of long-acting conjugates for type 2 diabetes therapeutics and in reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators.

Phthalimidooxy PEG-based cross linkers

Phthalimidooxy PEG-based cross linkers form stable oximes with aldehydes, also latent ones as present in carbohydrates. Their reactivity is sufficiently mild for a broad used in creating conjugates with sensitive biologics.

Prolines with Hydrophobic Substituents

Prolines are key elements positioned at the edge of β-turns in peptides. With modified prolines these positions can be used for either covalent amide or disulfide bonds – as we have demonstrated in many examples – or for filling hydrophobic pockets, whenever the pyrrolidine ring is substituted with groups like Methyl or Phenyl.

MiDye is YOUR Dye!

Superior Performance at a Sensational Price!

• Available as –COOH, -NHS, -Maleimide, -Alkyne, -Azide
• Half the price of other well-known dyes like Alexa- & Cy-Dyes.
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• Broadly applied in cell imaging, FRET, fluorescence quenching.

Diamines & Polyamines

Compounds like putrescine, spermidine, and spermine play important roles in a many biological functions. Many of them are excellent targets for oncology studies and other fields of medicinal chemistry.
Find in our new brochure Diamines & Polyamines our possibilities for custom synthesis and a set over 100 available derivatives.