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Visit this regularly updated section to check out the latest additions to our portfolio, as well as the latest developments at Iris Biotech.
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3rd Generation Click Chemistry: Tetrazine and TCO Derivatives for Copper-free Conjugation
The reaction between a tetrazine (Tz) and a trans-cyclooctene (TCO) is the innovative third generation Click reaction that proceeds without the use of copper or other catalyst. It is rapid, fully bioorthogonal and excels at very low concentrations.
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Fast and Easy Protease Kinetics with Asymmetric Rhodamine 110 Substrates
Asymmetric Rhodamine 110 protease substrates are used for the determination of protease kinetics. The asymmetric structure of these dyes greatly simplifies the determination of enzyme kinetics, while the properties of Rhodamine 110 facilitate an uncomplicated readout.
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THPTA: Ligand-accelerated Click Chemistry in Aqueous Solution
Polytriazole ligands such as THPTA accelerate the copper-catalyzed azide-alkyne cycloaddition (CuAAC), or “Click”, reaction. Moreover, with the use of further additives, polytriazoles facilitate CuAAC even in live cells by significantly lowering the bioavailability of the copper catalyst.
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Markers for the Quality of Food
Maillard Reaction Products (MRPs) result from the reaction of Arg and Lys side chains with reducing carbohydrates. MRPs are valuable markers for food quality and are used in many different branches of industry such as food, pharma, cosmetics and biochemistry.
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Furyl-Alanine: A Novel Photo-Click Amino Acid
2-Furyl-alanine can be incorporated into peptides via SPPS or by using enzymatic approaches. UV-irradiation in the presence of oxygen and a photosensitizer converts furyl-alanine to an intermediate that selectively reacts with certain nucleophiles. This property can be employed for site-specific labeling of peptides and proteins.
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Targeted and Reversible Biotinylation with Biotin-SS-Tyramide
Our new Biotin-SS-Tyramide linker is a valuable tool for peroxidase-promoted targeted protein biotinylation. By using peroxidase-tagged antibodies, proteins and protein clusters can be selectively biotinylated, and then isolated using streptavidin. The biotin tag can be subsequently removed using reducing agents (e.g. glutathione).
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Fmoc-Phe-Aca: Fluorescent Internalization Reporter for Cell Penetrating Peptides (CPPs)
The Fmoc-L-Phe-Aca pseudo-dipeptide is a useful reporter group for the successful internalization of CPPs. Phe quenches the fluorescence of Aca. Internalization of the peptide containing Phe-Aca leads to proteolytic cleavage of the Phe-Aca bond and thus to fluorescence.
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Inexpensive & High Quality Guanylation Reagents
We now offer N,N'-Bis-Boc-N"-triflylguanidine, at both a very competitive price and our habitual high quality. Find out about the usefulness of this and our other guanylation reagents!
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Siderophore Building Block: New Hydroxamate-Ornithine for Fmoc/tBu SPPS
Nδ-hydroxy-Nδ-acetyl-ornithine, an important constituent of many siderophores, is now available for your convenience as Nα-Fmoc-Nδ-(acetyl)-Nδ-(benzoyloxy)-ornithine building block which can be used in standard Fmoc/tBu SPPS and permits facile on-resin Nδ-deprotection.
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Click Chemistry Tools: Propargyl Amino Acids
Click chemistry is a convenient method to chemoselectively functionalize peptides at specific positions. We offer a variety of different propargyl amino acids for both Fmoc and Boc strategies, for enzymatic synthesis, as well as preloaded resins for SPPS.
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