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News
Visit this regularly updated section to check out the latest additions to our portfolio, as well as the latest developments at Iris Biotech.
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Peptoids - Peptide Backbone Derivatisation
Alkylating the Nitrogen of an amide bond results in peptoid structures, leading to conformational restrains, like N-methylation and allows backbone derivatisation. Applications already have been published with Cilengitide, Piscidin 1, and MC4 receptor agonist.
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Peptide Solutions Appointed as Distributor for Iris Biotech for all North American Sales
We at Iris Biotech, are pleased to announce that we have entered into an agreement with Peptide Solutions, LLC to sell the complete line of our products in the USA and Canada.
Peptide Solutions’ website has a link to our complete list of products so ordering online is extremely easy, however, personal contact is available at the phone listed above, Monday through Friday, 8am to 5pm MST.
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New Statin Analogues: Super-Threonine Derivatives
A set of new statin analogues, so called Super-Threonines, is available consisting of Fmoc protected L-enantiomers with all possible 4 stereoisomers of chiral centers in the side chain. They appear in nature as bridge building element in cyclodepsipeptides, like pipecolidepsin A, a compound which shows relevant cytotoxic activity in three human tumor cell lines (lung, colon, breast) and has unique structural features.
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4-Methylbenzhydryl-Resins - the Better Wang-Resin alternative
Wang resins are widely used for peptide synthesis. However, certain side reactions, like diketopiperazin formation limit their use. 4-Methylbenzhydryl resin needs more space and leaves less room for this type of side reactions. Standard “Wang-typical” Fmoc/tBu coupling protocols can be applied.
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New: Cysteine-Pseudoproline
Pseudoprolines derived from Serine and Threonine have developed to standard building blocks for peptide synthesis since their invention. Now this technology is also available with Cysteine residues, as the corresponding 2,4-dimethoxyphenyl-pseudothiaproline is compatible with standard Fmoc/tBu protocols.
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Amino Aldehydes
Aldehydes are between alcohols and carboxylic acids with respect to their oxidation level and show specific reactivity. Therefore they are highly interesting building blocks and intermediates for a large number of very interesting classes of reactions and compounds such as Wittig reaction, formation of secondary alcohols, heterocycles and semiaminals to name only a few.
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Improved Synthesis with Dmb-Glycine Dipeptide Building Blocks
Positions next to Glycine are often reasons for side reactions, as aspartamide or diketopiperazine formation can occur. Dmb and Tmb can be used for temporary protection of the amide nitrogen of a peptide bond, in order to solubilize the peptide and increase yield and purity.
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Linkers for Antibody-Drug Conjugation (ADC)
Cleavable dipeptide linkers like Val-Ala and Val-Cit rely on processes inside the cell to liberate the payload, as they undergo rapid hydrolysis in the presence of lysosomal extracts or purified human cathepsin B.
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Photocleavable Cys Protecting Group
This oNv (2-Nitroveratryl) is the latest addition to our repertoire of cysteine protecting groups. It opens new possibilities of orthogonality to the existing strategies for disulfide bridge formation.
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Copper-Free Click Conjugation
Many efforts have been undertaken to develop possibilities for copper-free Diels-Alder reaction based conjugation. Very promising options are Tetrazines and appropriate Dienophiles, as they are patent free and have potential for affordable bulk application.
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