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Fmoc-Val-Ala-PAB-PNP
Chemical name: 9-Fluorenylmethyloxycarbonyl-valyl-alanyl-(4-aminobenzyl)-(4-nitrophenyl)carbonate // Synonyms: (9H-fluoren-9-yl)methyl (S)-3-methyl-1-((S)-1-(4-(((4-nitrophenoxy)carbonyloxy)methyl)phenylamino)-1-oxo-5-ureidopentan-2-ylamino)-1-oxobutan-2-ylcarbamate
- Product code:ADC1070
- CAS No.:1394238-92-6
- Formula:C37H36N4O9
- Storage temperature:-20°C
- Molecular weight:680.71 g/mol
from $137.50
description
Linker for Antibody-Drug-Conjugation (ADC). The Val-Cit will specifically be cleaved by catepsin B. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell.
references
Laurent Ducry (ed.), Antibody-Drug Conjugates, Methods in Molecular Biology, vol. 1045, DOI 10.1007/978-1-62703-541-5_5, # Springer Science+Business Media, LLC 2013.
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