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Fmoc-L-Pro(4,4-F2)-OH
Chemical name: (S)-1-(9-Fluorenylmethyloxycarbonyl)-4,4-difluoro-pyrrolidine-2-carboxylic acid // Synonyms: (S)-Fmoc-4,4-difluoro-pyrrolidine-2-carboxylic acid, Fmoc-4,4-difluoro-proline, Fmoc-Pro(4,4,-F2)-OH
- Product code:FAA4290
- CAS No.:203866-21-1
- Formula:C20H17F2NO4
- Storage temperature:2-8°C
- Molecular weight:373.36 g/mol
from $187.50
references
MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV; A. G. Nair, Q. Zeng, O. Selyutin, S. B. Rosenblum, Y. Jiang, D. Y. Yang, K. Keertikar, G. Zhou, M. Dwyer, S. H. Kim, B. Shankar, W. Yu, L. Tong, L. Chen, R. Mazzola, J. Caldwell, H. Tang, S. Agrawal, R. Liu, R. Kong, P. Ingravallo, E. Xia, Y. Zhai, A. Nomeir, E. Asante-Appiah and J. A. Kozlowski; Bioorg Med Chem Lett 2018; 28: 1954-1957. https://doi.org/10.1016/j.bmcl.2018.03.049
The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer; V. J. Somovilla, I. A. Bermejo, I. S. Albuquerque, N. Martinez-Saez, J. Castro-Lopez, F. Garcia-Martin, I. Companon, H. Hinou, S. I. Nishimura, J. Jimenez-Barbero, J. L. Asensio, A. Avenoza, J. H. Busto, R. Hurtado-Guerrero, J. M. Peregrina, G. J. L. Bernardes and F. Corzana; J Am Chem Soc 2017; 139: 18255-18261. https://doi.org/10.1021/jacs.7b09447
Synthesis, biological evaluation and structural analysis of novel peripherally active morphiceptin analogs; A. Adamska, A. Kluczyk, M. C. Cerlesi, G. Calo, A. Janecka and A. Borics; Bioorg Med Chem 2016; 24: 1582-8. https://doi.org/10.1016/j.bmc.2016.02.034
Synthesis and Pharmacological Evaluation of alpha4beta2 Nicotinic Ligands with a 3-Fluoropyrrolidine Nucleus; L. Tamborini, A. Pinto, R. Ettari, C. Gotti, F. Fasoli, P. Conti and C. De Micheli; ChemMedChem 2015; 10: 1071-8. https://doi.org/10.1002/cmdc.201500073
Both the cis-trans equilibrium and isomerization dynamics of a single proline amide modulate beta2-microglobulin amyloid assembly; V. Y. Torbeev and D. Hilvert; Proc Natl Acad Sci U S A 2013; 110: 20051-6. https://doi.org/10.1073/pnas.1310414110
Origin of the stability conferred upon collagen by fluorination; M. D. Shoulders, K. J. Kamer and R. T. Raines; Bioorg Med Chem Lett 2009; 19: 3859-62. https://doi.org/10.1016/j.bmcl.2009.03.168
Proline editing: a divergent strategy for the synthesis of conformationally diverse peptides; K. M. Thomas, D. Naduthambi, G. Tririya and N. J. Zondlo; Org Lett 2005; 7: 2397-400. https://doi.org/10.1021/ol0506720
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