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Fmoc-L-Pro(4-NH-Pal)-OH (2S,4R)
Chemical name: (2S,4R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-palmitamidopyrrolidine-2-carboxylic acid
- Product code:FAA8900
- Formula:C36H50N2O5
- Storage temperature:2-8°C
- Molecular weight:590.81 g/mol
from $750.00
description
Fmoc protected proline with additional fatty acid functionalization. Lipidated “fatty” amino acids have a number of intriguing applications, the most well-known being the prolongation of circulation half-life of peptide therapeutics by binding to serum albumin.
references
Synthesis of Lipidated Peptides; F. Rosi, G. Triola; Peptide Synthesis and Applications 2013; 161-189. https://doi.org/10.1007/978-1-62703-544-6_12
Synthetic lipidation of peptides and amino acids: monolayer structure and properties; P. Berndt, G. B. Fields, M. Tirrell; J. Am. Chem. Soc. 1995; 117(37): 9515-9522. https://doi.org/10.1021/ja00142a019
Peptide Lipidation – A Synthetic Strategy to Afford Peptide Based Therapeutics; R. Kowalczyk, P. W. R. Harris, G. M. Williams, S.-H. Yang, M. A. Brimble; Peptides and Peptide-based Biomaterials and their Biomedical Applications 2017; 1030: 185-227. https://doi.org/10.1007/978-3-319-66095-0_9
Solid-Phase Synthesis of Lipidated Peptides; G. Kragol, M. Lumbierres, J. M. Palomo; H. Waldmann; Angew. Chem. Int. Ed. 2004; 116(43): 5963-5966. https://doi.org/10.1002/ange.200461150
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