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Fmoc-L-Glu(EDANS)-OH
Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-5-(2-(5-sulfonaphthalen-1-ylamino)ethylamido)-L-glutamic acid // Synonyms: Fmoc-Glu(EDANS)-OH, (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-oxo-5-(2-(5-sulfonaphthalen-1-ylamino)ethylamino)pentanoic acid,N-alpha-(9-Fluorenylmethyloxycarbonyl)-5-{[(2'-aminoethyl)-amino ]naphthelenesulfonic acid}-L-glutamic acid
- Product code:FAA4410
- CAS No.:193475-66-0
- Formula:C32H31N3O8S
- Storage temperature:2-8°C
- Molecular weight:617.67 g/mol
from $212.50
description
Building block for the SPPS of internally quenched fluorogenic peptide substrates (FRET substrates). The fluorescent group EDANS can be efficiently quenched by the non-fluorescent DABCYL chromophore (introduced by Fmoc-Lys(Dabcyl)-OH (FAA1498).
references
J.W. Drijfhout et al., Proceedings of the 14th American Peptide Symposium, p. 129, P.T.P. Kaumaya and R.S. Hodges, eds., Mayflower Scientific Ltd. England, (1996).
A general method for the preparation of internally quenched fluorogenic protease substrates using solid-phase peptide synthesis. Maggiora L.L., Smith C.W., Zhang Z.Y.; J. Med. Chem. 1992; 35(21): 3727-30.
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