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Fmoc-L-Glu(ODmab)-OH
Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-glutamic-acid-gamma-[N-{1-(4,4-dimethyl-2,6-dixocyclohexylidene-3-methylbutyl}amino]benzyl ester // Synonyms: 5-[[4-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]phenyl]methyl] hydrogen N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamate,(2S)-5-[[4-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)- 3-methylbutyl]amino]phenyl]methoxy]-2-(9H-fluoren-
- Product code:FAA8555
- CAS No.:268730-86-5
- Formula:C40H44N2O8
- Storage temperature:-20°C
- Molecular weight:680.80 g/mol
from $462.50
description
The 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl (Dmab) protecting group is compatible with the Fmoc/tert-butyl strategy used in standard peptide chemistry and is not cleaved during the final TFA treatment. Dmab esters are easily removed on solid phase or in solution using 2% hydrazine.
references
References:
A new photolabile carboxyl protecting group for native chemical ligation; B. Briand, N. Kotzur, V. Hagen, M. Beyermann; Tetrahedron Lett. 2008; 49(1): 85-87. https://doi.org/10.1016/j.tetlet.2007.11.028.
Development of Conformationally Constrained a-RgIAAnalogues as Stable Peptide Antagonists of Human a9a10Nicotinic Acetylcholine Receptors; N. Zheng, S. B. Christensen, A. Blakely, C. Dowel, L. Purushottam, J. M. McIntosh, D. H.-C. Chou; J. Med. Chem. 2020; 63(15): 8380-8387. https://doi.org/10.1021/acs.jmedchem.0c00613.
Secondary structural preferences of some antibacterial cyclooctapeptides in the presence of calcium(II); T. Stevens, N. McNeil, X. Lin, M. Ngu-Schwemlein; Int. J. Med. Chem. 2012. https://doi.org/10.1155/2012/730239.
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