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Fmoc-L-Lys(5-STrt, Boc)-OH
Chemical name: (2S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-6-((tert-butoxycarbonyl)amino)-5-(tritylthio)hexanoic acid // Synonyms: Fmoc-Lys(5-STrt, Boc)-OH
- Product code:FAA9335
- CAS No.:1240666-29-8
- Formula:C45H46N2O6S
- Storage temperature:-20°C
- Molecular weight:742.93 g/mol
from $5,000.00
description
Bicyclic peptides have high potential as next generation pharmaceuticals, e.g., to disrupt the difficult to target interactions between proteins. For controlled cyclization, selective reactivities are required. Our 1,2-aminothiol and 1,3-thiazole building blocks yield the ideal combination for this purpose, and, in addition, are compatible with SPPS. Besides, when used N-terminally, 1,2-aminothiols are useful for connecting peptide fragments by native chemical ligation (NCL).
references
Traceless and Site-Specific Ubiquitination of Recombinant Proteins; S. Virdee, P. B. Kapadnis, T. Elliott, K. Lang, J. Madrzak, D. P. Ngyuen, L. Riechmann, J. W. Chin; J. Am. Chem. Soc. 2011; 133(28): 10708–10711. https://doi.org/10.1021/ja202799r
Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin; F. El Oualid, R. Merkx, R. Ekkebus, D. S. Hameed, J. J. Smit, A. de Jong, H. Hilkmann, T. K. Sixma, H. Ovaa; Angew Chem Int Ed Engl. 2010; 49(52): 10149-53. https://doi.org/10.1002/anie.201005995
Protecting group variations of ä-mercaptolysine useful in chemical ubiquitylation; M. Haj-Yahya, K. S. A. Kumar, L. A. Erlich, A. Brik; Biopolymers 2010; 94(4): 504-510. https://doi.org/10.1002/bip.21384
Highly efficient and chemoselective peptide ubiquitylation; K. S. A. Kumar, M. Haj-Yahya, D. Olschewski, H. A. Lashuel, A. Brik; Angew Chem Int Ed Engl. 2009; 48(43): 8090-4. https://doi.org/10.1002/anie.200902936
Platform for Orthogonal N-Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents; A. Istrate, M. Geeson, C. Navo, B. Sousa, M. Marques, R. Taylor, T. Journeaux, S. Oehler, M. Mortensen, M. Deery, A. Bond, F. Corzana, G. Jiménez-Osés, G. Bernardes; JAmChemSoc. 2022; 144: 10396-10406. https://doi.org/10.1021/jacs.2c02185
Recent advances in N- and C-terminus cysteine protein bioconjugation; R. Spears, V. Chudasama; CurrOpinChemBiol. 2023; 75: 102306. https://doi.org/10.1016/j.cbpa.2023.102306
Biocompatible and Selective Generation of Bicyclic Peptides; S. Ullrich, J. George, A. Coram, R. Morewood, C. Nitsche; AngewChemIntEd. 2022; 61: e202208400. https://doi.org/10.1002/anie.202208400
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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