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Boc-L-Lys(Poc)-OH
Chemical name: (S)-2-(t-Butyloxycarbonylamino)-6-((prop-2-ynyloxy)carbonylamino)hexanoic acid // Synonyms: N-alpha-t-Butyloxycarbonyl-N-epsilon-(prop-2-ynyloxycarbonyl)-L-lysine, Boc-L-Lys(Pryoc)-OH, Boc-Lys(Poc)-OH
- Product code:BAA1960
- CAS No.:1202704-91-3
- Formula:C15H24N2O6
- Molecular weight:328.36 g/mol
- Purity :min. 97%
- Enantiomeric Purity:min. 99,7%
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description
tRNA can be loaded with the propargyl analogue of free L-lysine by pyrrolysyl-tRNA synthetase enabling the biochemist to introduce site specifically an alkyne group into a protein for further click conjugation.
references
Bioorthogonal Catalysis: A General Method To Evaluate Metal-Catalyzed Reactions in Real Time in Living Systems Using a Cellular Luciferase Reporter System; H. T. Hsu, B. M. Trantow, R. M. Waymouth and P. A. Wender; Bioconjug Chem 2016; 27: 376-82. https://doi.org/10.1021/acs.bioconjchem.5b00469
N-alkynyl derivatives of 5-fluorouracil: susceptibility to palladium-mediated dealkylation and toxigenicity in cancer cell culture; J. T. Weiss, C. Fraser, B. Rubio-Ruiz, S. H. Myers, R. Crispin, J. C. Dawson, V. G. Brunton, E. E. Patton, N. O. Carragher and A. Unciti-Broceta; Front Chem 2014; 2: 56. https://doi.org/10.3389/fchem.2014.00056
Palladium-triggered deprotection chemistry for protein activation in living cells; J. Li, J. Yu, J. Zhao, J. Wang, S. Zheng, S. Lin, L. Chen, M. Yang, S. Jia, X. Zhang and P. R. Chen; Nat Chem 2014; 6: 352-61. https://doi.org/10.1038/nchem.1887
Genetic encoding and labeling of aliphatic azides and alkynes in recombinant proteins via a pyrrolysyl-tRNA Synthetase/tRNA(CUA) pair and click chemistry; D. P. Nguyen, H. Lusic, H. Neumann, P. B. Kapadnis, A. Deiters and J. W. Chin; J Am Chem Soc 2009; 131: 8720-1. https://doi.org/10.1021/ja900553w
Direct charging of tRNACUA with pyrrolysine in vitro and in vivo; S. K. Blight, R. C. Larue, A. Mahapatra, D. G. Longstaff, E. Chang, G. Zhao, P. T. Kang, K. B. Green-Church, M. K. Chan and J. A. Krzycki; Nature 2004; 431: 333. https://doi.org/10.1038/nature02895
Propargyloxycarbonyl and propargyl groups for novel protection of amino, hydroxy, and carboxy functions; Y. Fukase, K. Fukase and S. Kusumoto; Tetrahedron Letters 1999; 40: 1169-1170. https://doi.org/10.1016/s0040-4039(98)02555-6
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