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H-L-Lys(MeTz-PhAc)-OH*TFA
Chemical name: N-(2-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl)acetyl)-L-lysine TFA salt // Synonyms: Tetrazin-lysine trifluoracetate, H-Lys(MeTz-PhAc)-OH*TFA
- Product code:HAA9170
- CAS No.:2578384-82-2 (net)
- Formula:C17H22N6O3*CF3COOH
- Storage temperature:-20°C
- Molecular weight:358.40*114.02 g/mol
from $843.75
description
Lysine building block carrying tetrazine suitable for 3rd generation Click conjugation with any suitable dienophile.
references
Inverse electron demand Diels-Alder (IEDDA) reactions in peptide chemistry; M. Pagel; Journal of peptide science : an official publication of the European Peptide Society 2019; 25: e3141. https://doi.org/10.1002/psc.3141
Bioorthogonal Fluorescence Turn-On Labeling Based on Bicyclononyne-Tetrazine Cycloaddition Reactions that Form Pyridazine Products; S. J. Siegl, J. Galeta, R. Dzijak, M. Dracinsky and M. Vrabel; Chempluschem 2019; 84: 493-497. https://doi.org/10.1002/cplu.201900176
An Extended Approach for the Development of Fluorogenic trans-Cyclooctene-Tetrazine Cycloadditions; S. J. Siegl, J. Galeta, R. Dzijak, A. Vazquez, M. Del Rio-Villanueva, M. Dracinsky and M. Vrabel; Chembiochem : a European journal of chemical biology 2019; 20: 886-890. https://doi.org/10.1002/cbic.201800711
Advances in Tetrazine Bioorthogonal Chemistry Driven by the Synthesis of Novel Tetrazines and Dienophiles; H. Wu and N. K. Devaraj; Acc Chem Res 2018; 51: 1249-1259. https://doi.org/10.1021/acs.accounts.8b00062
Bio-orthogonal Fluorescent Labelling of Biopolymers through Inverse-Electron-Demand Diels-Alder Reactions; E. Kozma, O. Demeter and P. Kele; Chembiochem : a European journal of chemical biology 2017; 18: 486-501. https://doi.org/10.1002/cbic.201600607
Bicyclo[6.1.0]nonyne and tetrazine amino acids for Diels–Alder reactions; X. Li, Z. Liu and S. Dong; RSC Advances 2017; 7: 44470-44473. https://doi.org/10.1039/c7ra08136g
Inverse electron demand Diels-Alder reactions in chemical biology; B. L. Oliveira, Z. Guo and G. J. L. Bernardes; Chem Soc Rev 2017; 46: 4895-4950. https://doi.org/10.1039/c7cs00184c
Click Chemistry and Radiochemistry: The First 10 Years; J. P. Meyer, P. Adumeau, J. S. Lewis and B. M. Zeglis; Bioconjug Chem 2016; 27: 2791-2807. https://doi.org/10.1021/acs.bioconjchem.6b00561
Highly accelerated inverse electron-demand cycloaddition of electron-deficient azides with aliphatic cyclooctynes; J. Dommerholt, O. van Rooijen, A. Borrmann, C. F. Guerra, F. M. Bickelhaupt and F. L. van Delft; Nat Commun 2014; 5: 5378. https://doi.org/10.1038/ncomms6378
The inverse electron demand Diels-Alder click reaction in radiochemistry; T. Reiner and B. M. Zeglis; J Labelled Comp Radiopharm 2014; 57: 285-90. https://doi.org/10.1002/jlcr.3149
3,6-Substituted-1,2,4,5-tetrazines: tuning reaction rates for staged labeling applications; D. Wang, W. Chen, Y. Zheng, C. Dai, K. Wang, B. Ke and B. Wang; Org Biomol Chem 2014; 12: 3950-5. https://doi.org/10.1039/c4ob00280f
trans-Cyclooctene--a stable, voracious dienophile for bioorthogonal labeling; R. Selvaraj and J. M. Fox; Curr Opin Chem Biol 2013; 17: 753-60. https://doi.org/10.1016/j.cbpa.2013.07.031
Inverse electron demand Diels-Alder (iEDDA)-initiated conjugation: a (high) potential click chemistry scheme; A. C. Knall and C. Slugovc; Chem Soc Rev 2013; 42: 5131-42. https://doi.org/10.1039/c3cs60049a
The growing impact of bioorthogonal click chemistry on the development of radiopharmaceuticals; D. Zeng, B. M. Zeglis, J. S. Lewis and C. J. Anderson; J Nucl Med 2013; 54: 829-32. https://doi.org/10.2967/jnumed.112.115550
Biomedical applications of tetrazine cycloadditions; N. K. Devaraj and R. Weissleder; Acc Chem Res 2011; 44: 816-27. https://doi.org/10.1021/ar200037t
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