Fmoc-D-Thr[Psi(Me,Me)Pro]-OH

Chemical name: (4R,5S)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-2,2,5-trimethyl-1,3-oxazolidine-4-carboxylic acid

  • Product code:PSI1650
  • CAS No.:159681-93-3
  • Formula:C22H23NO5
  • Molecular weight:381.43 g/mol
  • Purity :min.99%

Starting at $118.75

Grouped product items
Qty Packing unit Price SKU
1 g
$118.75
PSI1650.0001
5 g
$425.00
PSI1650.0005
25 g
$1,700.00
PSI1650.0025
description

D-Threonine-derived Pseudoproline monomer for SPPS. This building-block can be successfully coupled with many amino-acids using modern coupling techniques avoiding the need for pseudoproline dipeptides and giving the possibility to introduce pseudoprolines in peptides containing non-natural or rare amino-acids.


references

Solid-Phase Synthesis of an “Inaccessible” hGH-Derived Peptide Using a Pseudoproline Monomer and SIT-Protection for Cysteine; S. R. Manne, A. Chakraborty, K. Rustler, T. Bruckdorfer, B. G. de la Torre, F. Albericio; ACS Omega 2022; 7(32): 28487–28492. https://doi.org/10.1021/acsomega.2c03261

Scope and limitations of pseudoprolines as individual amino acids in peptide synthesis; D. A. Senko, N. D. Timofeev, I. E. Kasheverov, I. A. Ivanov; Amino Acids 2021; 53: 665–671. https://doi.org/10.1007/s00726-021-02973-1


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