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H-L-Cys(Clt)-2CT Resin
Chemical name: H-L-Cys(Clt)-2-chlorotrityl resin // Synonyms: H-Cys(Clt)-2CT Resin
- Product code:RAA1050
- Particle size :100-200 mesh
- DVB crosslinking :1% DVB
- Loading:> 0.4 mmol/g
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description
The Clt (2-chlorotrityl) protecting group is more stable than the commonly used Trt group and is best deprotected by oxidative methods with Iodine resulting in a simultaneous disulfide bridge formation. It is therefore best used in the synthesis of cyclic peptides with several disulfide bridges in particular for the synthesis of the second S-S bridge.
references
Aletras A., Barlos K. et al; Int. J. Pept. Protein Res. 1995; 45(5): 488-496.
Barlos K. et al; Int. J. Pept. Protein Res. 1991; 38(6): 555-561.
Sarah L.M. et al, in „Fmoc Solid Phase Synthesis. A practical approach“, Ed.: Chan W.C., White P.D. Oxford University Press 2000, page 177.
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