H-L-Cys(Clt)-2CT Resin

Chemical name: H-L-Cys(Clt)-2-chlorotrityl resin // Synonyms: H-Cys(Clt)-2CT Resin

  • Product code:RAA1050
  • Particle size :100-200 mesh
  • DVB crosslinking :1% DVB
  • Loading:> 0.4 mmol/g

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The Clt (2-chlorotrityl) protecting group is more stable than the commonly used Trt group and is best deprotected by oxidative methods with Iodine resulting in a simultaneous disulfide bridge formation. It is therefore best used in the synthesis of cyclic peptides with several disulfide bridges in particular for the synthesis of the second S-S bridge.


Aletras A., Barlos K. et al; Int. J. Pept. Protein Res. 1995; 45(5): 488-496.

Barlos K. et al; Int. J. Pept. Protein Res. 1991; 38(6): 555-561.

Sarah L.M. et al, in „Fmoc Solid Phase Synthesis. A practical approach“, Ed.: Chan W.C., White P.D. Oxford University Press 2000, page 177.

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