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H-L-Glu(2CT resin)-OtBu
Chemical name: L-Glutamate alpha-t-butyl ester-gamma-(2-chlorotrityl resin) ester // Synonyms: H-Glu(2CT resin)-OtBu
- Product code:RAA2700
- Particle size :100-200 mesh
- DVB crosslinking :1% DVB
- Loading:ca. 0.5 mmol/g
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description
Very acid labile resin, which enables synthesis of peptide acids.
Peptides can be cleaved as protected fragments, which enables very easy in-process control of the success and completion of any coupling step. Very useful also for the synthesis of head-tail cyclic peptides or peptide modifiers.
references
K. Barlos et all. WO 2013/098802 A2.
K. Barlos, D. Gatos et all., Int. J. Peptide and Protein Res. 1991; 38: 555-561.
K. Barlos and D. Gatos, in Fmoc solid phase peptide synthesis, edit. W.C. Chan and P. D. White, Oxford University Press, 2000.
Attachment of Histidine, Histamine and Urocanic acid to Resins of the Trityl-Type. Eleftheriou, S.; Gatos, D.; Panagopoulos, A.; Stathopoulos, S.; Barlos, K.; Tetrahedron Letters 1999; 40(14): 2825-2828.
G. Sabatino et all, Tetrahedron Letters 1999; 40: 809-812.
E. Atherton et. all. US 7,691,968 B2.
F. Albericio et. all WO 2008/040536 A1.
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