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Fmoc-L-His(Mmt resin)-NH2
Chemical name: Fmoc-L-Histidine alpha-amide-Nim-(4-methoxytrityl resin) // Synonyms: Fmoc-His(Mmt resin)-NH2
- Product code:RAA2640
- Particle size :100-200 mesh
- DVB crosslinking :1% DVB
- Loading:ca. 0.5 mmol/g
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description
Very acid labile resin, which enables synthesis of peptide amides without the use of amide linkers (Rink, Ramage, Sieber, etc.)
Peptides can be cleaved as protected fragments, which enables very easy in-process control of the success and completion of any coupling step.
references
K. Barlos et al. WO 2013/098802 A2.
K. Barlos, D. Gatos et al., Int. J. Peptide and Protein Res. 1991; 38: 555-561.
K. Barlos and D. Gatos, in Fmoc solid phase peptide synthesis, edit. W.C. Chan and P. D. White, Oxford University Press, 2000.
Attachment of Histidine, Histamine and Urocanic acid to Resins of the Trityl-Type. Eleftheriou, S.; Gatos, D.; Panagopoulos, A.; Stathopoulos, S.; Barlos, K.; Tetrahedron Letters 1999; 40(14): 2825-2828.
G. Sabatino et al, Tetrahedron Letters 1999; 40: 809-812.
E. Atherton et. al. US 7,691,968 B2.
F. Albericio et. al WO 2008/040536 A1.
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