COMU ®

Chemical name: 1-[1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylamino-morpholino]-uronium hexafluorophosphate

  • Product code:RL-1175
  • CAS No.:1075198-30-9
  • Storage temperature:2-8°C
  • Formula:C12H19N4O4PF6
  • Molecular weight:428.26 g/mol

from $113.75

Grouped product items
Qty Packing unit Price SKU Availability
25 g
$113.75
RL-1175.0025
<10 business days
100 g
$343.75
RL-1175.0100
<10 business days
250 g
$687.50
RL-1175.0250
<10 business days
1 kg
$2,000.00
RL-1175.1000
<10 business days
Safety Data Sheets
description

COMU is an efficient coupling reagent requiring one equivalent of base during bond formation as it liberates morpholine. Typical applications are amide bond formation, eg. in both solution and solid phase synthesis at room temperature or with conventional heating or microwave. Minimized racemization. Supposed to be non-allergenic. Couplings can be monitored visually or colourimetrically due to color change from yellow to orange; the reagent shows excellent solubility in DMF and NMP.

references

R. Subirós-Funosas, R. Prohens, R. Barbas, A. El-Faham, F. Albericio; Chem. Eur. J. 2009; 15: 9394-9403.

A. El-Faham, F. Albericio; J. Pept. Sci. 2010; 16: 6-9.

R. Subiros-Funosas, S. N. Khattab, L. Nieto-Rodriguez, A. El-Faham, F. Albericio; Aldrichim. Acta 2013; 46: 21-40.

A. El-Faham, R. S. Funosas, R. Prohens, F. Albericio; Chem. Eur. J. 2009; 15: 9404-9416.

R. Subiros-Funosas, G. A. Acosta, A. El-Faham, F. Albericio; Tetrahedron Lett. 2009; 50: 6200-6202.

A. El-Faham and F. Albericio, J. Org. Chem. 2008; 73: 2731.

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