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PyAOP
Chemical name: (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinyl-phosphorus hexafluorophosphate // Synonyms: (1H-7-Azabenzotriazole-1-yl)-oxy-tris-pyrrolidino-phosphonium hexafluorophosphat
- Product code:RL-1210
- CAS No.:156311-83-0
- Formula:C17H27N7OP*PF6
- Molecular weight:376.42*144.96 g/mol
from $150.00
description
Coupling reagent for peptide synthesis, disulfide bond engineering, and heteroaryl ether synthesis. Optimization of conformational constraint on non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.
Applications reported for the synthesis of cyclic RGC pentapeptides with functionalization through click chemistry.
references
A Practical Large-Scale Synthesis of Cyclic RGD Pentapeptides Suitable for Further Functionalization through ‘Click’ Chemistry; J. Palecek, G. Dräger and A. Kirschning; Synthesis 2011; 2011: 653-661. https://dx.doi.org/10.1055/s-0030-1258396
ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing; C. F. Carter, H. Lange, S. V. Ley, I. R. Baxendale, B. Wittkamp, J. G. Goode and N. L. Gaunt; Organic Process Research & Development 2010; 14: 393-404. https://dx.doi.org/10.1021/op900305v
Development of Fluorescent Glucose Bioprobes and Their Application on Real-Time and Quantitative Monitoring of Glucose Uptake in Living Cells; H. Y. Lee, J. J. Lee, J. Park and S. B. Park; Chemistry - A European Journal 2011; 17: 143-150. https://dx.doi.org/10.1002/chem.201002560
Modulating Oxytocin Activity and Plasma Stability by Disulfide Bond Engineering; M. Muttenthaler, A. Andersson, A. D. de Araujo, Z. Dekan, R. J. Lewis and P. F. Alewood; Journal of Medicinal Chemistry 2010; 53: 8585-8596. https://dx.doi.org/10.1021/jm100989w
Heteroaryl Ethers by Oxidative Palladium Catalysis of Pyridotriazol-1-yloxy Pyrimidines with Arylboronic Acids; S. Bardhan, S. Wacharasindhu, Z.-K. Wan and T. S. Mansour; Organic Letters 2009; 11: 2511-2514. https://dx.doi.org/10.1021/ol900592b
Global optimization of conformational constraint on non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain; Y.-Q. Long, F.-D. T. Lung and P. P. Roller; Bioorganic & Medicinal Chemistry 2003; 11: 3929-3936. http://dx.doi.org/10.1016/S0968-0896(03)00411-5
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