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Biotin-Pen-CBT
Chemical name: N-(5-((2-cyano-6-benzothiazolyl)amino)-5-oxopentyl)-biotin // Synonyms: N-(2-cyanobenzo[d]thiazol-6-yl)-5-biotinyl-pentanamide, CBT-pentanoyl-biotin, Biotin-pentanoyl-CBT, Biotin-pentanoyl-cyanobenzothiazole, Biotin-C5-CBT, BPCBT, CBTP-Biotin
- Product code:RL-4240
- CAS No.:2550397-17-4
- Formula:C23H28N6O3S2
- Molecular weight:500.64 g/mol
from $250.00
description
The site-specific labeling of proteins by chemical reactions has gained increased interest for the investigation of cellular processes. In this regard, the CBT-Cys „click“ condensation reaction has found wide applicability in recent years. The reaction is highly biocompatible and controllable and runs under physiological conditions. It is based on the condensation between an N-terminal L- or D-Cysteine with the cyano group of CBT.
references
N, S-Double Labeling of N-Terminal Cysteines via an Alternative Conjugation Pathway with 2-Cyanobenzothiazole; W. Wang, J. Gao; J. Org. Chem. 2020, 85(3): 1756–1763. https://doi.org/10.1021/acs.joc.9b02959
Novel Regioselective Approach to Cyclize Phage-Displayed Peptides in Combination with Epitope-Directed Selection to Identify a Potent Neutralizing Macrocyclic Peptide for SARS-CoV-2; J. T. Hampton, T. J. Lalonde, J. M. Tharp, Y. Kurra, Y. R. Alugubelli, C. M. Roundy, G. L. Hamer, S. Xu, W. R. Liu; ACS Chem. Biol. 2022, 17(10): 2911–2922. https://doi.org/10.1021/acschembio.2c00565
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