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N3-PEG(3)-SQA
Chemical name: 3-((2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)amino)-4-ethoxycyclobut-3-ene-1,2-dione // Synonyms: N3-PEG3-NH-SQ-OEt, Azido-PEG3-Ethylsquaramide, SQ-PEG3-N3, N3-PEG3-Squarate
- Product code:RL-4420
- CAS No.:2920089-51-4
- Formula:C14H22N4O6
- Molecular weight:342.35 g/mol
- Purity :min. 98,0%
from $112.50
description
A clickable PEG linker that can be reacted with amines and other nucleophiles.
This monoester amide has a high hydrolytic stability at alkaline pH making it superior bioconjugation tool when compared to conventional activated esters.
references
RAFT Polymer–Antibody Conjugation: Squaramide Ester Chemistry Leads to Conjugates with a Therapeutic Anti-EGFR Antibody with Full Retention of Activity and Increased Tumor Uptake In Vivo; A. Ardana, S. Ghosh, P. Huda, N. L. Fletcher, K. J. Thurecht, C. C. Williams; Mol. Pharmaceutics 2023; 20(6): 3073–3087. https://doi.org/10.1021/acs.molpharmaceut.3c00085
WO2023049963A1
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