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Suc-CBT
Chemical name: 4-((2-cyanobenzo[d]thiazol-6-yl)amino)-4-oxobutanoic acid // Synonyms: CBT-Suc, Succinyl-CBT, 4-[(2-Cyano-6-benzothiazolyl)amino]-4-oxobutanoic acid, CBT-Suc-OH, CBT-C4-OH, CBT-Succinic acid, CBT-4-oxobutanoic acid
- Product code:RL-4300
- CAS No.:1207457-67-1
- Formula:C12H9N3O3S
- Molecular weight:275.28 g/mol
from $375.00
description
The site-specific labeling of proteins by chemical reactions has gained increased interest for the investigation of cellular processes. In this regard, the CBT-Cys „click“ condensation reaction has found wide applicability in recent years. The reaction is highly biocompatible and controllable and runs under physiological conditions. It is based on the condensation between an N-terminal L- or D-Cysteine with the cyano group of CBT.
references
Deciphering the Cellular Targets of Bioactive Compounds Using a Chloroalkane Capture Tag; R. F. Ohana, T. A. Kirkland, C. C. Woodroofe, S. Levin, H. T. Uyeda, P. Otto, R. Hurst, M. B. Robers, K. Zimmermann, L. P. Encell, K. V. Wood; ACS Chem Biol 2015, 10(10):2316-24. https://doi.org/10.1021/acschembio.5b00351
Mechanistic study of CBT-Cys click reaction and its application for identifying bioactive N-terminal cysteine peptides in amniotic fluid; Z. Zheng, P. Chen, G. Li, Y. Zhu, Z. Shi, Y. Luo, C. Zhao, Z. Fu, X. Cui, C. Ji, F. Wang, G. Huang, G. Liang; Chem. Sci. 2017, 8: 214-222. https://doi.org/10.1039/C6SC01461E
Utilizing a Simple Method for Stoichiometric Protein Labeling to Quantify Antibody Blockade; R. F. Ohana, R. Hurst, M. Rosenblatt, S. Levin, T. Machleidt, T. A. Kirkland, L. P. Encell, M. B. Robers, K. V. Wood; Sci Rep 2019, 9: 7046. https://doi.org/10.1038/s41598-019-43469-z
Thiol-Cyanobenzothiazole Ligation for the Efficient Preparation of Peptide–PNA Conjugates; N. A. Patil, J. A. Karas, B. J. Turner, F. Shabanpoor; Bioconjugate Chem. 2019, 30 (3): 793–799. https://doi.org/10.1021/acs.bioconjchem.8b00908
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