Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
EUR
Contact rapide
Veuillez m'envoyer plus d'informations sur
Fmoc-L-Lys(tBuO-Thap)-OH
Nom chimique: N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-(16-(tert-butoxy)-16-oxohexadecanoyl)-L-lysine // Synonymes: Fmoc-Lys(tBuO-Thap)-OH, Fmoc-Lys(tBuO-Thapsic Acid)-OH, Fmoc-L-Lys(tBuO-Thapsic Acid)-OH
- n° Art.:FAA8990
- n° CAS:2952671-06-4
- Formule:C41H60N2O7
- Storage temperature:2-8°C
- Masse moléculaire:692,94 g/mol
from 1 500,00 €
description
Lipidated “fatty” amino acids have a number of intriguing applications, the most well-known being the prolongation of circulation half-life of peptide therapeutics by binding to serum albumin. In comparison, fatty diacids outperform the monoacids.
references
Synthesis of Lipidated Peptides; F. Rosi, G. Triola; Peptide Synthesis and Applications 2013; 161-189. https://doi.org/10.1007/978-1-62703-544-6_12
Synthetic lipidation of peptides and amino acids: monolayer structure and properties; P. Berndt, G. B. Fields, M. Tirrell; J. Am. Chem. Soc. 1995; 117(37): 9515-9522. https://doi.org/10.1021/ja00142a019
Peptide Lipidation – A Synthetic Strategy to Afford Peptide Based Therapeutics; R. Kowalczyk, P. W. R. Harris, G. M. Williams, S.-H. Yang, M. A. Brimble; Peptides and Peptide-based Biomaterials and their Biomedical Applications 2017; 1030: 185-227. https://doi.org/10.1007/978-3-319-66095-0_9
Solid-Phase Synthesis of Lipidated Peptides; G. Kragol, M. Lumbierres, J. M. Palomo; H. Waldmann; Angew. Chem. Int. Ed. 2004; 116(43): 5963-5966. https://doi.org/10.1002/ange.200461150
Derivatization with fatty acids in peptide and protein drug discovery; P. Kurtzhals, S. Østergaard, E. Nishimura, T. Kjeldsen; Nat. Rev. 2023; 22: 59-80. https://doi.org/10.1038/s41573-022-00529-w
S. Østergaard, J. F. Paulsson, J. Kofoed, F. Zosel, J. Olsen, C. Bekker Jeppesen, J. Spetzler, L. Ynddal, L. Gram Schleiss, B. Østergaard Christoffersen, K. Raun, U. Sensfuss, F. Ser Nielsen, R. Jørgensen, B. S. Wulff; Scientific Reports 2021; 11: 21179. https://doi.org/10.1038/s41598-021-00654-3
* Disclaimer
We refer to our general terms and conditions.
All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
Besoin d'informations supplémentaires sur ce produit?
entrer en contact
Brochures et dépliants
Des produits qui pourraient également vous intéresser!
