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H-L-Lys(Palm)-OMe*HCl
Nom chimique: Methyl N-epsilon-palmitoyl-L-lysine hydrochloride // Synonymes: Methyl N6-palmitoyl-L-lysinate, Methyl N-epsilon-palmitoyl-L-lysinate, Methyl N6-palmitoyl-L-lysine hydrochloride, H-Lys(Palm)-OMe*HCl, N6-Palmitoyl-L-lysine methyl esterhydrochloride, 890082-89-0 ( net CAS), H-Lys(Palm)-OMe*HCl
- n° Art.:HAA9225
- n° CAS:890026-44-5
- Storage temperature:2-8°C
- Formule:C23H46N2O3*HCl
- Masse moléculaire:398,63*36,46 g/mol
- Pureté:min. 98%
- Pureté Énantiomérique:min. 99,7%
from 108,00 €
description
This fatty-acid modified Lysine building block is investigated for its use in surfactant, micelle, and nanoparticle research. It can be used to introduce lipophilic chains into peptides. Fatty Amino Acids are reported to improve the pharmacokinetic and pharmacologic properties of peptide APIs and other biopharmaceuticals. Serum lifetimes can be drastically improved as the fatty acid residue helps to bind temporarily to serum albumin. This enhances stability towards proteolytic degradation.
references
Cationic surfactants from lysine: Synthesis, micellization and biological evaluation; L. Perez, A. Pinazo, M. Teresa Garcia, M. Lozano, A. Manresa, M. Angelet, M. Pilar Vinardell, M. Mitjans, R. Pons, M. Rosa Infante; Eur. J. Med. Chem. 2009; 44(5): 1884-1892. https://doi.org/10.1016/j.ejmech.2008.11.003.
Self Assembly of pH-Sensitive Cationic Lysine Based Surfactants; A. Mezei, L. Perez, A. Pinazo, F. Comelles, M. Rosa Infante, R. Pons; Langmuir 2012; 28(49): 16761-16771. https://doi.org/10.1021/la304117f.
Basic peptides containing fatty acids and their antibacterial activity; K. Vogler, P. Lanz, P. Quitt, R. O. Studer, W. Lergier, E. Boehni, B. Frust; Helv. Chim. Acta 1964; 47(2): 526-44.
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