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H-L-Lys(COCF2N3)-OH*HCl
Nom chimique: N6-(2-azido-2,2-difluoroacetyl)-L-lysine // Synonymes: H-Lys(COCF2N3)-OH*HCl, (2S)-2-Amino-6-(2-azido-2,2-difluoroacetamido)hexanoic acid, Azidodifluoroacetil lysine hydrochloride
- n° Art.:HAA9295
- Formule:C8H13F2N5O3*HCl
- Storage temperature:2-8°C
- Masse moléculaire:265,22*36,46 g/mol
- Pureté:min. 98%
- Pureté Énantiomérique:min. 99,7%
from 120,00 €
description
This NCAA can be incorporated into proteins for better click-conjugation. This difluoro-analogue shows a >2-fold increase in reactivity towards copper-free conjugation with BCN in comparison with the azido-acetyl analogue.
references
References:
Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody-Drug Conjugates; R. van Geel, M. A. Wijdeven, R. Heesbeen, J. M. M. Verkade, A. A. Wasiel, S. S. van Berkel, F. L. van Delft; Bioconjugate Chem. 2015; 26(11): 2233-2242. https://doi.org/10.1021/acs.bioconjchem.5b00224
N-Difluoromethyl-triazole as a constrained scaffold in peptidomimetics; M. Mamone, R. S. B. Gonçalves, F. Blanchard, G. Bernadat, S. Ongeri, T. Milcent, B. Crousse; Chem. Commun. 2017; 53: 5024-5027. https://doi.org/10.1039/C7CC01298E
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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