Search results for: 'Amine PEG'

PotM: Versatile TentaGel® Resins

Discover the diversity of TentaGel® Resins ! Read our blog to get more information about our latest product additions and possible applications and find the right resin for your research endeavors!

Amino-Li Resin – A Novel Solid Support

Shaken, not stirred. Amino-Li resin – a cross-linked polyacrylic amide solid support suitable for the synthesis of peptides and biomolecules, which is compatible with organic as well as aqueous solvents.

PotM: Oleyl-Poly(Sarcosines) for Drug Delivery

Novel excipients can help you master the challenges associated with the production and formulation of protein- and RNA-based drugs due to their inherent fragility. Discover the SURPAX TM technology!

Bifunctional TentaGel® Resins

Encode beads with unique tags for combinatorial syntheses & screening. Build libraries & identify hits. Discover properties and applications of our novel bifunctional TentaGel® resins.

Selective Lysine Labeling with Squaric Acid

Keeping control! PEGylating reagents with a squaric acid ethyl ester react chemoselectively with side chain amino functions of surface-accessible Lysines in proteins. Other functionalities are not affected.

PotM: Functionalized Dextrans

Our monofunctionalized dextrans are enriching the toolbox of polymer therapeutics – Dextrans benefit of excellent solubility, biocompatibility, biodegradability, and non-immunogenicity.

Choose your Taste – Functionalized Halo/Snap/Clip Substrates

The HaloTag®, SNAP-Tag® and CLIP-Tag TM represent versatile tools for the specific, covalent attachment of in principle any molecule of choice to a protein of interest. Discover our substrates!

Sarcosine Building Blocks

Interested in the introduction of Sarcosine (N-methylglycine), e.g. for hydrophilicity increase of your derivative of choice or for PEG replacement? Check-out our available Sarcosine building blocks!

Building Blocks for the Introduction of Hydroxylamine

Herein, we present building blocks for the synthesis of protected hydroxylamine derivatives which can be further used for bio-conjugation and various other applications. Read on to find out more!

PotM: Functionalized Biotinylation Reagents

Iris Biotech offers a variety of (functionalized) biotin and desthiobiotin reagents reactive towards certain functional groups. Discover our growing portfolio and latest additions.

Enzymatically Cleavable Linkers Based on Val-Cit and Val-Ala

The peptide-based ADC linkers Val-Cit and Val-Ala are efficiently cleaved by lysosomal proteases and benefit from increased serum stability and effective payload-release in targeted cells.

Thiol- and Amine Reactive Crosslinkers

Iris Biotech offers hetero-bifunctional crosslinkers bearing an N-hydroxysuccinimide (NHS) ester and a maleimide group suitable for the reaction with amine- and thiol-containing molecules.

Product Focus: Arginine Derivatives

Looking to optimize or functionalize your peptide? Explore our ever-growing selection of Arg derivatives and find the one suitable for your application.

Product of the Month: Dde-based Linkers

Placing Dde as one terminal group of a linker and a functional group prone for conjugation as the other or using Dde as the central connective portion of a linker, allows for the creation of new bifunctional linkers.

Subject Focus: Linkerology

The ever-growing sophistication and variation in linker design have given rise to a new and distinct field of knowledge in synthetic chemistry termed Linkerology. Discover our expertise and panoply of new cutting-edge tailor-made linker constructs for the latest state-of-the-art bioconjugations.

Mercapto-PEG-Acids for Bioconjugation

Mercapto-PEG-Acids are highly hydrophilic, non-antigenic, non-immunogenic and non-toxic.

Click Chemistry in DNA Synthesis

Click Chemistry in DNA Synthesis - Applications and Procedures in DNA Synthesis

Specific Linkers

The variations for linkers are endless, as in our catalogue program already hundreds of different derivatives are available for conjugation of small molecules, biomolecules and surfaces to each other.

Poly(Glutamic Acid) as Versatile Biodegradable Drug Carrier

Polyglutamates are well known to be highly biocompatible, biodegradable and multifunctional polymers, which have already been used as building blocks in polymer drug conjugates and polymeric micelles.

Polysarcosine – a True Alternative to PEG

Potential alternatives to PEGs, polypeptoids in general and polysarcosine (PSR) in particular stand out in terms of safety, synthetic control and versatility.

Amino-PEG-Acids and their Active Esters

Amino protected amino-PEG-acids can be used for the PEGylation of solid particles in order to create hydrophilic and reactive surfaces with no non-specific binding issues.

PEG-Conjugates of Folic Acid and Cholesterol

Conjugates of PEG and folic acid or cholesterol, respectively, combine the positive properties of these molecules. Those conjugates are available with a wide variety of functional groups and different PEG chain lengths to suit your needs.

New: dPEG-Phospholipids for superior liposomes

Novel liposomes built of dPEG-Phospholipids with defined PEG chain length provide prolonged blood-circulation time and improved cellular uptake as administration carriers for drugs, delivering active molecules to the desired target.

Biotin Tyramide Reagents for Tyrosine-/Protein-Biotinylation

Tyramine compounds are converted to highly reactive radicals by horseradish peroxidase in presence of H2O2 which preferentially react with surface exposed tyrosines. Biotin Tyramide and Biotin-PEG-Tyramide therefore are ideal reagents used for tyrosine-/protein-biotinylation.

Bis-Mal-Lysine

Bis Thiol & Amine reactive PEGylated Cross-Linker which has been used for enhanced receptor binding, for the design of long-acting conjugates for type 2 diabetes therapeutics and in reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators.

Phthalimidooxy PEG-based cross linkers

Phthalimidooxy PEG-based cross linkers form stable oximes with aldehydes, also latent ones as present in carbohydrates. Their reactivity is sufficiently mild for a broad used in creating conjugates with sensitive biologics.